RT Journal Article
T1 Ulcerative Colitis and Crohn's Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk.
A1 Castro Aguilar-Tablada, Teresa
A1 Navarro-Alarcón, Miguel
A1 Quesada Granados, Javier
A1 Samaniego Sánchez, Cristina
A1 Rufián-Henares, José Ángel
A1 Nogueras-Lopez, Flor
K1 Ulcerative colitis;
K1 Crohn’s disease
K1 Selenium
K1 Influencing factors
K1 Nutritional and biochemical markers
K1 Antioxidantes
K1 Biomarcadores
K1 Índice de masa corporal
K1 Enfermedades cardiovasculares
K1 Colesterol
K1 Colinesterasas
K1 Colitis ulcerosa
K1 Enfermedad de Crohn
K1 Hematócrito
K1 Hemoglobinas
K1 Humanos
K1 Incidencia
K1 Inflamación
K1 Enfermedades inflamatorias del intestino
K1 Estado nutricional
K1 Estrés oxidativo
K1 Prealbúmina
K1 Hierro
K1 Factores de riesgo
K1 Selenio
AB The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn's disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p < 0.001) and significantly lower in CD patients than in UC patients (p = 0.006). Se concentrations in patients were significantly influenced by sex, body mass index (BMI), the inflammatory biomarker α-1-antitrypsin, surgery, medical treatment, the severity, extent, and form of the disease and the length of time since onset (p < 0.05). Se concentrations in IBD patients were positively and linearly correlated with nutritional (protein, albumin, prealbumin, cholinesterase and total cholesterol) and iron status-related (hemoglobin, Fe and hematocrit) parameters (p < 0.05). A greater impairment of serum Se and cardiovascular status was observed in CD than in UC patients. An adequate nutritional Se status is important in IBD patients to minimize the cardiovascular risk associated with increased inflammation biomarkers, especially in undernourished CD patients, and is also related to an improved nutritional and body iron status.
PB MDPI
YR 2016
FD 2016-12-01
LK http://hdl.handle.net/10668/2624
UL http://hdl.handle.net/10668/2624
LA en
NO Castro Aguilar-Tablada T, Navarro-Alarcón M, Quesada Granados J, Samaniego Sánchez C, Rufián-Henares JÁ, Nogueras-Lopez F. Ulcerative Colitis and Crohn's Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk. Nutrients. 2016                         ; 8(12)
NO Journal Article;
DS RISalud
RD Apr 20, 2025