TY  - JOUR
AU  - Cismaru, Anca Liliana
AU  - Grimm, Livia
AU  - Rudin, Deborah
AU  - Ibanez, Luisa
AU  - Liakoni, Evangelia
AU  - Bonadies, Nicolas
AU  - Kreutz, Reinhold
AU  - Hallberg, Par
AU  - Wadelius, Mia
AU  - Haschke, Manuel
AU  - Largiader, Carlo R.
AU  - Amstutz, Ursula
AU  - EuDAC Collaborators
PY  - 2020
DO  - 10.3389/fgene.2020.00951
UR  - https://hdl.handle.net/10668/28247
T2  - Frontiers in genetics
AB  - Background and Objective:Agranulocytosis is a rare and potentially life-threatening complication of metamizole (dipyrone) intake that is characterized by a loss of circulating neutrophil granulocytes. While the mechanism underlying this adverse drug...
LA  - en
PB  - Frontiers media sa
KW  - drug-induced agranulocytosis
KW  - metamizole (dipyrone)
KW  - HLA
KW  - pharmacogenetics
KW  - high-throughput sequencing
KW  - next generation sequencing
KW  - genetic association studies
KW  - Induced liver-injury
KW  - Blood dyscrasias
KW  - High-resolution
KW  - Read alignment
KW  - Hypersensitivity
KW  - Genotype
KW  - Allele
KW  - Loci
KW  - Hla-b-asterisk-5701
KW  - Safety
TI  - High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
TY  - research article
VL  - 11
ER  -