TY  - JOUR
AU  - López-Isac, Elena
AU  - Campillo-Davo, Diana
AU  - Bossini-Castillo, Lara
AU  - Guerra, Sandra G
AU  - Assassi, Shervin
AU  - Simeón, Carmen Pilar
AU  - Carreira, Patricia
AU  - Ortego-Centeno, Norberto
AU  - García de la Peña, Paloma
AU  - Spanish Scleroderma Group
AU  - Beretta, Lorenzo
AU  - Santaniello, Alessandro
AU  - Bellocchi, Chiara
AU  - Lunardi, Claudio
AU  - Moroncini, Gianluca
AU  - Gabrielli, Armando
AU  - Riemekasten, Gabriela
AU  - Witte, Torsten
AU  - Hunzelmann, Nicolas
AU  - Kreuter, Alexander
AU  - Distler, Jörg Hw
AU  - Voskuyl, Alexandre E
AU  - de Vries-Bouwstra, Jeska
AU  - Herrick, Ariane
AU  - Worthington, Jane
AU  - Denton, Christopher P
AU  - Fonseca, Carmen
AU  - Radstake, Timothy Rdj
AU  - Mayes, Maureen D
AU  - Martín, Javier
PY  - 2015
DO  - 10.1136/annrheumdis-2015-208154
UR  - http://hdl.handle.net/10668/10172
T2  - Annals of the rheumatic diseases
AB  - TYK2 is a common genetic risk factor for several autoimmune diseases. This gene encodes a protein kinase involved in interleukin 12 (IL-12) pathway, which is a well-known player in the pathogenesis of systemic sclerosis (SSc). Therefore, we aimed to...
LA  - en
KW  - Cytokines
KW  - Gene Polymorphism
KW  - Systemic Sclerosis
KW  - Treatment
KW  - Case-Control Studies
KW  - Genetic Predisposition to Disease
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Interleukin-12
KW  - Mutation, Missense
KW  - Polymorphism, Single Nucleotide
KW  - Scleroderma, Systemic
KW  - Signal Transduction
KW  - TYK2 Kinase
TI  - Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.
TY  - research article
VL  - 75
ER  -