TY  - JOUR
AU  - Calvanese, Vincenzo
AU  - Horrillo, Angelica
AU  - Hmadcha, Abdelkrim
AU  - Suarez-Alvarez, Beatriz
AU  - Fernandez, Agustín F
AU  - Lara, Ester
AU  - Casado, Sara
AU  - Menendez, Pablo
AU  - Bueno, Clara
AU  - Garcia-Castro, Javier
AU  - Rubio, Ruth
AU  - Lapunzina, Pablo
AU  - Alaminos, Miguel
AU  - Borghese, Lodovica
AU  - Terstegge, Stefanie
AU  - Harrison, Neil J
AU  - Moore, Harry D
AU  - Brüstle, Oliver
AU  - Lopez-Larrea, Carlos
AU  - Andrews, Peter W
AU  - Soria, Bernat
AU  - Esteller, Manel
AU  - Fraga, Mario F
PY  - 2008
DO  - 10.1371/journal.pone.0003294
UR  - http://hdl.handle.net/10668/765
T2  - PloS One
AB  - Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in...
LA  - en
PB  - Public library of Science
KW  - Chromatin
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::L Cells (Cell Line)
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::Chromatin
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylation
KW  - Medical Subject Headings::Anatomy::Cells::Stem Cells::Embryonic Stem Cells
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Developmental
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic::Gene Silencing
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Neoplasm
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Neoplasm
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::HeLa Cells
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Diseases::Neoplasms
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components
KW  - Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factors
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::U937 Cells
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation
TI  - Cancer genes hypermethylated in human embryonic stem cells.
TY  - research article
ER  -