RT Journal Article
T1 Cancer genes hypermethylated in human embryonic stem cells.
A1 Calvanese, Vincenzo
A1 Horrillo, Angelica
A1 Hmadcha, Abdelkrim
A1 Suarez-Alvarez, Beatriz
A1 Fernandez, Agustín F
A1 Lara, Ester
A1 Casado, Sara
A1 Menendez, Pablo
A1 Bueno, Clara
A1 Garcia-Castro, Javier
A1 Rubio, Ruth
A1 Lapunzina, Pablo
A1 Alaminos, Miguel
A1 Borghese, Lodovica
A1 Terstegge, Stefanie
A1 Harrison, Neil J
A1 Moore, Harry D
A1 Brüstle, Oliver
A1 Lopez-Larrea, Carlos
A1 Andrews, Peter W
A1 Soria, Bernat
A1 Esteller, Manel
A1 Fraga, Mario F
K1 Chromatin
AB Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in human stem cells and suggest that, for genes repressed by promoter hypermethylation in stem cells in vivo, the aberrant process in cancer could be understood as a defect in establishing an unmethylated promoter during differentiation, rather than as an anomalous process of de novo hypermethylation.
PB Public library of Science
YR 2008
FD 2008-09-29
LK http://hdl.handle.net/10668/765
UL http://hdl.handle.net/10668/765
LA en
NO Calvanese V, Horrillo A, Hmadcha A, Suarez-Alvarez B, Fernandez AF, Lara E, et al. Cancer genes hypermethylated in human embryonic stem cells. PLoS ONE; 3(9):e3294
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 17, 2025