RT Journal Article
T1 Glomerular Hematuria: Cause or Consequence of Renal Inflammation?
A1 Moreno, Juan Antonio
A1 Sevillano, Angel
A1 Gutierrez, Eduardo
A1 Guerrero-Hue, Melania
A1 Vazquez-Carballo, Cristina
A1 Yuste, Claudia
A1 Herencia, Carmen
A1 Garcia-Caballero, Cristina
A1 Praga, Manuel
A1 Egido, Jesus
K1 AKI
K1 Chronic kidney disease (CKD)
K1 Hematuria
K1 Inflammation
K1 Oxidative stress
K1 Tubular injury
AB Glomerular hematuria is a cardinal symptom of renal disease. Glomerular hematuria may be classified as microhematuria or macrohematuria according to the number of red blood cells in urine. Recent evidence suggests a pathological role of persistent glomerular microhematuria in the progression of renal disease. Moreover, gross hematuria, or macrohematuria, promotes acute kidney injury (AKI), with subsequent impairment of renal function in a high proportion of patients. In this pathological context, hemoglobin, heme, or iron released from red blood cells in the urinary space may cause direct tubular cell injury, oxidative stress, pro-inflammatory cytokine production, and further monocyte/macrophage recruitment. The aim of this manuscript is to review the role of glomerular hematuria in kidney injury, the role of inflammation as cause and consequence of glomerular hematuria, and to discuss novel therapies to combat hematuria.
PB MDPI
YR 2019
FD 2019-04-28
LK http://hdl.handle.net/10668/13916
UL http://hdl.handle.net/10668/13916
LA en
NO Moreno JA, Sevillano Á, Gutiérrez E, Guerrero-Hue M, Vázquez-Carballo C, Yuste C, et al. Glomerular Hematuria: Cause or Consequence of Renal Inflammation? Int J Mol Sci. 2019 May 5;20(9):2205
DS RISalud
RD Apr 20, 2025