RT Journal Article
T1 Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus.
A1 López-Villodres, Juan Antonio
A1 Abdel-Karim, Miriam
A1 De La Cruz, José Pedro
A1 Rodríguez-Pérez, María Dolores
A1 Reyes, José Julio
A1 Guzmán-Moscoso, Rocío
A1 Rodriguez-Gutierrez, Guillermo
A1 Fernández-Bolaños, Juan
A1 González-Correa, José Antonio
K1 Diabetes
K1 Hydroxytyrosol
K1 Inflammatory mediators
K1 Oxidative stress
K1 Platelets
K1 Vasculopathy
AB The aim of this study was to assess the influence of hydroxytyrosol (HT) on cardiovascular biomarkers and morphometric parameters of the arterial wall in streptozotocin-diabetic rats. Seven groups of rats (N=10 per group) were studied for 2 months: nondiabetic rats (NDR), diabetic rats treated with saline (DR) and DR treated with HT (0.5, 1, 2.5, 5 and 10 mg kg-1 day-1 p.o.). DR had higher platelet aggregation values, higher thromboxane B2, plasma lipid peroxidation, 3-nitrotyrosine, oxidized LDL (oxLDL), myeloperoxidase, vascular cell adhesion molecule 1 (VCAM-1) and interleukin-1β (IL-1β) concentrations, and lower aortic 6-keto-prostaglandin F1α and nitric oxide production than NDR. Aortic wall area and smooth muscle cell count were also higher in DR than in NDR. HT significantly reduced both oxidative and nitrosative stress, oxLDL concentration, VCAM-1 and inflammatory mediators, platelet aggregation and thromboxane B2 production. Morphometric values in the aortic wall were reduced to values near those in NDR. In conclusion, HT influenced the major biochemical processes leading to diabetic vasculopathy, and reduced cell proliferation in the vascular wall in this experimental model.
YR 2016
FD 2016-08-26
LK http://hdl.handle.net/10668/10463
UL http://hdl.handle.net/10668/10463
LA en
DS RISalud
RD Apr 12, 2025