RT Journal Article
T1 BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis.
A1 Prieto-Peña, Diana
A1 Genre, Fernanda
A1 Remuzgo-Martínez, Sara
A1 Pulito-Cueto, Verónica
A1 Atienza-Mateo, Belén
A1 Llorca, Javier
A1 Sevilla-Pérez, Belén
A1 Ortego-Centeno, Norberto
A1 Lera-Gómez, Leticia
A1 Leonardo, María Teresa
A1 Peñalba, Ana
A1 Narváez, Javier
A1 Martín-Penagos, Luis
A1 Rodrigo, Emilio
A1 Miranda-Filloy, José A
A1 Caminal-Montero, Luis
A1 Collado, Paz
A1 Pérez, Javier Sánchez
A1 de Argila, Diego
A1 Rubio, Esteban
A1 Luque, Manuel León
A1 Blanco-Madrigal, Juan María
A1 Galíndez-Agirregoikoa, Eva
A1 Gualillo, Oreste
A1 Martín, Javier
A1 Castañeda, Santos
A1 Blanco, Ricardo
A1 González-Gay, Miguel A
A1 López-Mejías, Raquel
AB BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants were analysed independently. Likewise, no statistically significant differences were found in the genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic network underlying IgAV.
YR 2021
FD 2021-06-01
LK http://hdl.handle.net/10668/17941
UL http://hdl.handle.net/10668/17941
LA en
DS RISalud
RD Apr 5, 2025