RT Journal Article
T1 Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells.
A1 Florido, Javier
A1 Rodriguez-Santana, Cesar
A1 Martinez-Ruiz, Laura
A1 Lopez-Rodriguez, Alba
A1 Acuña-Castroviejo, Dario
A1 Rusanova, Iryna
A1 Escames, Germaine
K1 apoptosis
K1 cancer
K1 melatonin
K1 mitochondria
K1 reactive oxygen species
AB Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. In this context, tumor cells have an altered redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death. Melatonin is of particular importance in the development of innovative cancer treatments due to its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic clinical applications.
PB MDPI AG
SN 2076-3921
YR 2022
FD 2022-08-19
LK http://hdl.handle.net/10668/20789
UL http://hdl.handle.net/10668/20789
LA en
NO Florido J, Rodriguez-Santana C, Martinez-Ruiz L, López-Rodríguez A, Acuña-Castroviejo D, Rusanova I, e al. Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells. Antioxidants (Basel). 2022 Aug 20;11(8):1621.
DS RISalud
RD Apr 16, 2025