RT Journal Article
T1 The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer
A1 Palma, Pablo
A1 Conde-Muíño, Raquel
A1 Rodríguez-Fernández, Antonio
A1 Segura-Jiménez, Inmaculada
A1 Sánchez-Sánchez, Rocío
A1 Martín-Cano, Javier
A1 Gómez-Río, Manuel
A1 Ferrón, José A
A1 Llamas-Elvira, José M
K1 Adulto
K1 Anciano
K1 Anciano de 80 o más Años
K1 Carcinoma
K1 Quimioterapia
K1 Terapia Combinada
K1 Femenino
K1 Fluorodesoxiglucosa F18
K1 Humanos
K1 Masculino
K1 Mediana Edad
K1 Tomografía de Emisión de Positrones
K1 Valor Predictivo de las Pruebas
K1 Pronóstico
K1 Neoplasias del Recto
K1 Sensibilidad y Especificidad
AB Background: We aim to investigate the possibility of using 18F-positron emission tomography/computer tomography (PET-CT) to predict the histopathologic response in locally advanced rectal cancer (LARC) treated with preoperative chemoradiation (CRT). Methods: The study included 50 patients with LARC treated with preoperative CRT. All patients were evaluated by PET-CT before and after CRT, and results were compared to histopathologic response quantified by tumour regression grade (patients with TRG 1-2 being defined as responders and patients with grade 3-5 as non-responders). Furthermore, the predictive value of metabolic imaging for pathologic complete response (ypCR) was investigated. Results: Responders and non-responders showed statistically significant differences according to Mandard's criteria for maximum standardized uptake value (SUVmax) before and after CRT with a specificity of 76,6% and a positive predictive value of 66,7%. Furthermore, SUVmax values after CRT were able to differentiate patients with ypCR with a sensitivity of 63% and a specificity of 74,4% (positive predictive value 41,2% and negative predictive value 87,9%); This rather low sensitivity and specificity determined that PET-CT was only able to distinguish 7 cases of ypCR from a total of 11 patients. Conclusions: We conclude that 18-F PET-CT performed five to seven weeks after the end of CRT can visualise functional tumour response in LARC. In contrast, metabolic imaging with 18-F PET-CT is not able to predict patients with ypCR accurately
PB BioMed Central
YR 2010
FD 2010-12-15
LK http://hdl.handle.net/10668/409
UL http://hdl.handle.net/10668/409
LA en
NO Palma P, Conde-Muíño R, Rodríguez-Fernández A, Segura-Jiménez I, Sánchez-Sánchez R, Martín-Cano J, et al. The value of metabolic imaging to predict tumour response after chemoradiation in  locally advanced rectal cancer. Radiat Oncol. 2010 Dec 15;5:119
NO Preliminary data of this work were presented by RCM and awarded at the 2009 Annual Meeting of the Spanish Society of Coloproctology (AECP) held in Barcelona.
DS RISalud
RD Apr 7, 2025