%0 Journal Article
%A Palma, Pablo
%A Conde-Muíño, Raquel
%A Rodríguez-Fernández, Antonio
%A Segura-Jiménez, Inmaculada
%A Sánchez-Sánchez, Rocío
%A Martín-Cano, Javier
%A Gómez-Río, Manuel
%A Ferrón, José A
%A Llamas-Elvira, José M
%T The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer
%D 2010
%U http://hdl.handle.net/10668/409
%X Background: We aim to investigate the possibility of using 18F-positron emission tomography/computer tomography (PET-CT) to predict the histopathologic response in locally advanced rectal cancer (LARC) treated with preoperative chemoradiation (CRT). Methods: The study included 50 patients with LARC treated with preoperative CRT. All patients were evaluated by PET-CT before and after CRT, and results were compared to histopathologic response quantified by tumour regression grade (patients with TRG 1-2 being defined as responders and patients with grade 3-5 as non-responders). Furthermore, the predictive value of metabolic imaging for pathologic complete response (ypCR) was investigated. Results: Responders and non-responders showed statistically significant differences according to Mandard's criteria for maximum standardized uptake value (SUVmax) before and after CRT with a specificity of 76,6% and a positive predictive value of 66,7%. Furthermore, SUVmax values after CRT were able to differentiate patients with ypCR with a sensitivity of 63% and a specificity of 74,4% (positive predictive value 41,2% and negative predictive value 87,9%); This rather low sensitivity and specificity determined that PET-CT was only able to distinguish 7 cases of ypCR from a total of 11 patients. Conclusions: We conclude that 18-F PET-CT performed five to seven weeks after the end of CRT can visualise functional tumour response in LARC. In contrast, metabolic imaging with 18-F PET-CT is not able to predict patients with ypCR accurately
%K Adulto
%K Anciano
%K Anciano de 80 o más Años
%K Carcinoma
%K Quimioterapia
%K Terapia Combinada
%K Femenino
%K Fluorodesoxiglucosa F18
%K Humanos
%K Masculino
%K Mediana Edad
%K Tomografía de Emisión de Positrones
%K Valor Predictivo de las Pruebas
%K Pronóstico
%K Neoplasias del Recto
%K Sensibilidad y Especificidad
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