RT Journal Article
T1 Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease.
A1 Lopez-Campos, José Luis
A1 Miravitlles, Marc
A1 de la Rosa Carrillo, David
A1 Cantón, Rafael
A1 Soler-Cataluña, Juan Jose
A1 Martinez-Garcia, Miguel Angel
K1 COPD
K1 chronic bronchial infection
K1 potentially pathogenic microorganism
AB Currently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identified, which should be considered as goals for research. One of these is to establish the bases for identifying the biological and clinical implications of the presence of potentially pathogenic microorganisms in the airways that should be more clearly elucidated according to the COPD phenotype. Another urgent area of research is the role of long-term preventive antibiotics. Clinical trials need to be carried out with inhaled antibiotic therapy to help clarify the profile of those antibiotics. The role of inhaled corticosteroids in patients with COPD and CBI needs to be studied to instruct the clinical management of these patients. Finally, it should be explored and confirmed whether a suitable antimicrobial treatment during exacerbations may contribute to breaking the vicious circle of CBI in COPD. The present review addresses the current state of the art in these areas to provide evidence which will enable us to progressively plan better healthcare for these patients.
SN 2077-0383
YR 2020
FD 2020-05-28
LK https://hdl.handle.net/10668/27145
UL https://hdl.handle.net/10668/27145
LA en
DS RISalud
RD Apr 19, 2025