RT Journal Article
T1 Clinical intervals and diagnostic characteristics in a cohort of prostate cancer patients in Spain: a multicentre observational study.
A1 Bonfill, Xavier
A1 Martinez-Zapata, María J.
A1 Vernooij, Robin W.
A1 Sanchez-Perez, Maria-Jose
A1 Morales Suárez-Varela, María
A1 de la Cruz, Javier
A1 Emparanza, José I.
A1 Ferrer, Montserrat
A1 Pijoán, José I.
A1 Ramos-Goñi, Juan M.
A1 Palou, Joan
A1 Schmidt, Stefanie
A1 Abraira, Víctor
A1 Zamora, Javier
K1 Prostatic neoplasms
K1 Male urogenital diseases,
K1 Multicentre study
K1 Cohort study
K1 Prospective study
K1 Adenocarcinoma
K1 Humanos
K1 Masculino
K1 Clasificación del Tumor
K1 Neoplasias de la Próstata
K1 España
AB BACKGROUNDLittle is known about the healthcare process for patients with prostate cancer, mainly because hospital-based data are not routinely published. The main objective of this study was to determine the clinical characteristics of prostate cancer patients, the, diagnostic process and the factors that might influence intervals from consultation to diagnosis and from diagnosis to treatment.METHODSWe conducted a multicentre, cohort study in seven hospitals in Spain. Patients' characteristics and diagnostic and therapeutic variables were obtained from hospital records and patients' structured interviews from October 2010 to September 2011. We used a multilevel logistic regression model to examine the association between patient care intervals and various variables influencing these intervals (age, BMI, educational level, ECOG, first specialist consultation, tumour stage, PSA, Gleason score, and presence of symptoms) and calculated the odds ratio (OR) and the interquartile range (IQR). To estimate the random inter-hospital variability, we used the median odds ratio (MOR).RESULTS470 patients with prostate cancer were included. Mean age was 67.8 (SD: 7.6) years and 75.4 % were physically active. Tumour size was classified as T1 in 41.0 % and as T2 in 40 % of patients, their median Gleason score was 6.0 (IQR:1.0), and 36.1 % had low risk cancer according to the D'Amico classification. The median interval between first consultation and diagnosis was 89 days (IQR:123.5) with no statistically significant variability between centres. Presence of symptoms was associated with a significantly longer interval between first consultation and diagnosis than no symptoms (OR:1.93, 95%CI 1.29-2.89). The median time between diagnosis and first treatment (therapeutic interval) was 75.0 days (IQR:78.0) and significant variability between centres was found (MOR:2.16, 95%CI 1.45-4.87). This interval was shorter in patients with a high PSA value (p = 0.012) and a high Gleason score (p = 0.026).CONCLUSIONSMost incident prostate cancer patients in Spain are diagnosed at an early stage of an adenocarcinoma. The period to complete the diagnostic process is approximately three months whereas the therapeutic intervals vary among centres and are shorter for patients with a worse prognosis. The presence of prostatic symptoms, PSA level, and Gleason score influence all the clinical intervals differently.
PB BioMed Central
YR 2015
FD 2015-07-02
LK http://hdl.handle.net/10668/1935
UL http://hdl.handle.net/10668/1935
LA en
NO Bonfill X, Martinez-Zapata MJ, Vernooij RW, Sánchez MJ, Suárez-Varela MM, de la Cruz J, et al. Clinical intervals and diagnostic characteristics in a cohort of prostate cancer patients in Spain: a multicentre observational study. BMC Urol 2015; 15:60
NO Journal Article;
DS RISalud
RD Apr 17, 2025