RT Journal Article
T1 Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study.
A1 Mallorqui-Bague, Nuria
A1 Lozano-Madrid, Maria
A1 Toledo, Estefania
A1 Corella, Dolores
A1 Salas-Salvado, Jordi
A1 Cuenca-Royo, Aida
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Martinez, J Alfredo
A1 Wärnberg, Julia
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Bueno-Cavanillas, Aurora
A1 Alonso-Gomez, Angel
A1 Tur, Josep A
A1 Tinahones, Francisco J
A1 Serra-Majem, Lluis
A1 Martin, Vicente
A1 Lapetra, Jose
A1 Vazquez, Clotilde
A1 Pinto, Xavier
A1 Vidal, Josep
A1 Daimiel, Lidia
A1 Gaforio, Jose J
A1 Matia, Pilar
A1 Ros, Emilio
A1 Granero, Roser
A1 Buil-Cosiales, Pilar
A1 Barragan, Rocio
A1 Bullo, Monica
A1 Castañer, Olga
A1 Garcia-de-la-Hera, Manoli
A1 Yañez, Aina M
A1 Abete, Itziar
A1 Garcia-Rios, Antonio
A1 Ruiz-Canela, Miguel
A1 Diaz-Lopez, Andres
A1 Jimenez-Murcia, Susana
A1 Martinez-Gonzalez, Miguel A
A1 De la Torre, Rafael
A1 Fernandez-Aranda, Fernando
K1 Aged
K1 Body mass index
K1 Cognitive dysfunction
K1 Cross-sectional studies
AB This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53mmol/mol. Ourresults provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
PB Nature Publishing Group
YR 2018
FD 2018-10-31
LK http://hdl.handle.net/10668/13146
UL http://hdl.handle.net/10668/13146
LA en
NO Mallorquí-Bagué N, Lozano-Madrid M, Toledo E, Corella D, Salas-Salvadó J, Cuenca-Royo A, et al. Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. Sci Rep. 2018 Oct 31;8(1):16128
NO We thank the PREDIMED-PLUS Biobank Network, as a part of the National Biobank Platform of the Carlos III Health Institute (ISCIII) for storing and managing the PREDIMED-PLUS biological samples. Contract Juan Rodésfrom the Instituto de Salud Carlos III to Olga Castañer (JR17/00022) is duly acknowledged. Tis project is funded by Instituto de Salud Carlos III (ISCIII), the Spanish Government Ofcial Agency for funding biomedical research -with competitive grants for the periods 2014–2016, 2015–2017, 2017–2019 and 2018–2020, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund [grants:PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728 PI13/01090 PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215,PI17/01441, PI17/00508, PI17/01732, PI17/00926] and the European Research Council [Advanced Research Grant 2014–2019; agreement #340918]. Additional grants: Acciones Especiales from ISCIIII, Consejería-Salud, Junta -Andalucía [PI0458/2013, PS0358/2016], Recercaixa-grant 2013 [2013ACUP00194], a SEMERGEN grant, International Nut & Dried Fruit Council – FESNAD No. 201302. Fundación Patrimonio Comunal Olivarero is providing the necessary amounts of olive oil. Nuts were initially and only partially provided by Pistachios Growers and Almond Board of California, for the pilot study. Tis research was also partially funded by EU-H2020 Grant (Eat2beNICE/H2020-SFS-2016–2; Ref 728018), PI14/00290 y PI17/1167(Co-funded by European Regional Development Fund, ERDF, a way to build Europe), PERIS (Generalitat de Catalunya, SLT006/17/00077), Grant PROMETEO/2017/017 (Generalitat Valenciana) and Grant FEA/SEA 2017 for Primary Care Research. We thank CERCA Programme/Generalitat de Catalunya for institutional support. ML-M is supported by a predoctoral Grant of the Ministerio de Educación, Cultura y Deporte the design, collection, analysis, or interpretation of the data or in the decision to submit manuscripts for publication
DS RISalud
RD Apr 9, 2025