RT Journal Article
T1 Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study.
A1 Solans, Marta
A1 Castelló, Adela
A1 Benavente, Yolanda
A1 Marcos-Gragera, Rafael
A1 Amiano, Pilar
A1 Gracia-Lavedan, Esther
A1 Costas, Laura
A1 Robles, Claudia
A1 Gonzalez-Barca, Eva
A1 de la Banda, Esmeralda
A1 Alonso, Esther
A1 Aymerich, Marta
A1 Campo, Elias
A1 Dierssen-Sotos, Trinidad
A1 Fernández-Tardón, Guillermo
A1 Olmedo-Requena, Rocio
A1 Gimeno, Eva
A1 Castaño-Vinyals, Gemma
A1 Aragonés, Nuria
A1 Kogevinas, Manolis
A1 de Sanjose, Silvia
A1 Pollán, Marina
A1 Casabonne, Delphine
AB Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.
YR 2018
FD 2018-06-28
LK http://hdl.handle.net/10668/12657
UL http://hdl.handle.net/10668/12657
LA en
DS RISalud
RD Apr 12, 2025