RT Journal Article
T1 Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
A1 Fehringer, Gordon
A1 Kraft, Peter
A1 Pharoah, Paul D
A1 Eeles, Rosalind A
A1 Chatterjee, Nilanjan
A1 Schumacher, Fredrick R
A1 Schildkraut, Joellen M
A1 Lindström, Sara
A1 Brennan, Paul
A1 Bickeböller, Heike
A1 Houlston, Richard S
A1 Landi, Maria Teresa
A1 Caporaso, Neil
A1 Risch, Angela
A1 Amin Al Olama, Ali
A1 Berndt, Sonja I
A1 Giovannucci, Edward L
A1 Grönberg, Henrik
A1 Kote-Jarai, Zsofia
A1 Ma, Jing
A1 Muir, Kenneth
A1 Stampfer, Meir J
A1 Stevens, Victoria L
A1 Wiklund, Fredrik
A1 Willett, Walter C
A1 Goode, Ellen L
A1 Permuth, Jennifer B
A1 Risch, Harvey A
A1 Reid, Brett M
A1 Bezieau, Stephane
A1 Brenner, Hermann
A1 Chan, Andrew T
A1 Chang-Claude, Jenny
A1 Hudson, Thomas J
A1 Kocarnik, Jonathan K
A1 Newcomb, Polly A
A1 Schoen, Robert E
A1 Slattery, Martha L
A1 White, Emily
A1 Adank, Muriel A
A1 Ahsan, Habibul
A1 Aittomäki, Kristiina
A1 Baglietto, Laura
A1 Blomquist, Carl
A1 Canzian, Federico
A1 Czene, Kamila
A1 Dos-Santos-Silva, Isabel
A1 Eliassen, A Heather
A1 Figueroa, Jonine D
A1 Flesch-Janys, Dieter
A1 Fletcher, Olivia
A1 Garcia-Closas, Montserrat
A1 Gaudet, Mia M
A1 Johnson, Nichola
A1 Hall, Per
A1 Hazra, Aditi
A1 Hein, Rebecca
A1 Hofman, Albert
A1 Hopper, John L
A1 Irwanto, Astrid
A1 Johansson, Mattias
A1 Kaaks, Rudolf
A1 Kibriya, Muhammad G
A1 Lichtner, Peter
A1 Liu, Jianjun
A1 Lund, Eiliv
A1 Makalic, Enes
A1 Meindl, Alfons
A1 Müller-Myhsok, Bertram
A1 Muranen, Taru A
A1 Nevanlinna, Heli
A1 Peeters, Petra H
A1 Peto, Julian
A1 Prentice, Ross L
A1 Rahman, Nazneen
A1 Sanchez-Perez, Maria-Jose
A1 Schmidt, Daniel F
A1 Schmutzler, Rita K
A1 Southey, Melissa C
A1 Tamimi, Rulla
A1 Travis, Ruth C
A1 Turnbull, Clare
A1 Uitterlinden, Andre G
A1 Wang, Zhaoming
A1 Whittemore, Alice S
A1 Yang, Xiaohong R
A1 Zheng, Wei
A1 Buchanan, Daniel D
A1 Casey, Graham
A1 Conti, David V
A1 Edlund, Christopher K
A1 Gallinger, Steven
A1 Haile, Robert W
A1 Jenkins, Mark
A1 Le Marchand, Loïc
A1 Li, Li
A1 Lindor, Noralene M
A1 Schmit, Stephanie L
A1 Thibodeau, Stephen N
A1 Woods, Michael O
A1 Rafnar, Thorunn
A1 Gudmundsson, Julius
A1 Stacey, Simon N
A1 Stefansson, Kari
A1 Sulem, Patrick
A1 Chen, Y Ann
A1 Tyrer, Jonathan P
A1 Christiani, David C
A1 Wei, Yongyue
A1 Shen, Hongbing
A1 Hu, Zhibin
A1 Shu, Xiao-Ou
A1 Shiraishi, Kouya
A1 Takahashi, Atsushi
A1 Bossé, Yohan
A1 Obeidat, Ma'en
A1 Nickle, David
A1 Timens, Wim
A1 Freedman, Matthew L
A1 Li, Qiyuan
A1 Seminara, Daniela
A1 Chanock, Stephen J
A1 Gong, Jian
A1 Peters, Ulrike
A1 Gruber, Stephen B
A1 Amos, Christopher I
A1 Sellers, Thomas A
A1 Easton, Douglas F
A1 Hunter, David J
A1 Haiman, Christopher A
A1 Henderson, Brian E
A1 Hung, Rayjean J
A1 Ovarian Cancer Association Consortium (OCAC), 
A1 PRACTICAL Consortium, 
A1 Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), 
A1 Colorectal Transdisciplinary (CORECT) Study, 
A1 African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC), 
AB Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.
YR 2016
FD 2016-04-20
LK http://hdl.handle.net/10668/10103
UL http://hdl.handle.net/10668/10103
LA en
DS RISalud
RD Apr 4, 2025