%0 Journal Article
%A Fehringer, Gordon
%A Kraft, Peter
%A Pharoah, Paul D
%A Eeles, Rosalind A
%A Chatterjee, Nilanjan
%A Schumacher, Fredrick R
%A Schildkraut, Joellen M
%A Lindström, Sara
%A Brennan, Paul
%A Bickeböller, Heike
%A Houlston, Richard S
%A Landi, Maria Teresa
%A Caporaso, Neil
%A Risch, Angela
%A Amin Al Olama, Ali
%A Berndt, Sonja I
%A Giovannucci, Edward L
%A Grönberg, Henrik
%A Kote-Jarai, Zsofia
%A Ma, Jing
%A Muir, Kenneth
%A Stampfer, Meir J
%A Stevens, Victoria L
%A Wiklund, Fredrik
%A Willett, Walter C
%A Goode, Ellen L
%A Permuth, Jennifer B
%A Risch, Harvey A
%A Reid, Brett M
%A Bezieau, Stephane
%A Brenner, Hermann
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A Hudson, Thomas J
%A Kocarnik, Jonathan K
%A Newcomb, Polly A
%A Schoen, Robert E
%A Slattery, Martha L
%A White, Emily
%A Adank, Muriel A
%A Ahsan, Habibul
%A Aittomäki, Kristiina
%A Baglietto, Laura
%A Blomquist, Carl
%A Canzian, Federico
%A Czene, Kamila
%A Dos-Santos-Silva, Isabel
%A Eliassen, A Heather
%A Figueroa, Jonine D
%A Flesch-Janys, Dieter
%A Fletcher, Olivia
%A Garcia-Closas, Montserrat
%A Gaudet, Mia M
%A Johnson, Nichola
%A Hall, Per
%A Hazra, Aditi
%A Hein, Rebecca
%A Hofman, Albert
%A Hopper, John L
%A Irwanto, Astrid
%A Johansson, Mattias
%A Kaaks, Rudolf
%A Kibriya, Muhammad G
%A Lichtner, Peter
%A Liu, Jianjun
%A Lund, Eiliv
%A Makalic, Enes
%A Meindl, Alfons
%A Müller-Myhsok, Bertram
%A Muranen, Taru A
%A Nevanlinna, Heli
%A Peeters, Petra H
%A Peto, Julian
%A Prentice, Ross L
%A Rahman, Nazneen
%A Sanchez-Perez, Maria-Jose
%A Schmidt, Daniel F
%A Schmutzler, Rita K
%A Southey, Melissa C
%A Tamimi, Rulla
%A Travis, Ruth C
%A Turnbull, Clare
%A Uitterlinden, Andre G
%A Wang, Zhaoming
%A Whittemore, Alice S
%A Yang, Xiaohong R
%A Zheng, Wei
%A Buchanan, Daniel D
%A Casey, Graham
%A Conti, David V
%A Edlund, Christopher K
%A Gallinger, Steven
%A Haile, Robert W
%A Jenkins, Mark
%A Le Marchand, Loïc
%A Li, Li
%A Lindor, Noralene M
%A Schmit, Stephanie L
%A Thibodeau, Stephen N
%A Woods, Michael O
%A Rafnar, Thorunn
%A Gudmundsson, Julius
%A Stacey, Simon N
%A Stefansson, Kari
%A Sulem, Patrick
%A Chen, Y Ann
%A Tyrer, Jonathan P
%A Christiani, David C
%A Wei, Yongyue
%A Shen, Hongbing
%A Hu, Zhibin
%A Shu, Xiao-Ou
%A Shiraishi, Kouya
%A Takahashi, Atsushi
%A Bossé, Yohan
%A Obeidat, Ma'en
%A Nickle, David
%A Timens, Wim
%A Freedman, Matthew L
%A Li, Qiyuan
%A Seminara, Daniela
%A Chanock, Stephen J
%A Gong, Jian
%A Peters, Ulrike
%A Gruber, Stephen B
%A Amos, Christopher I
%A Sellers, Thomas A
%A Easton, Douglas F
%A Hunter, David J
%A Haiman, Christopher A
%A Henderson, Brian E
%A Hung, Rayjean J
%A Ovarian Cancer Association Consortium (OCAC)
%A PRACTICAL Consortium
%A Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
%A Colorectal Transdisciplinary (CORECT) Study
%A African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC)
%T Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
%D 2016
%U http://hdl.handle.net/10668/10103
%X Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.
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