RT Journal Article
T1 Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation.
A1 García-Martínez, Olga
A1 De Luna-Bertos, Elvira
A1 Ramos-Torrecillas, Javier
A1 Ruiz, Concepción
A1 Milia, Egle
A1 Lorenzo, María Luisa
A1 Jimenez, Brigida
A1 Sánchez-Ortiz, Araceli
A1 Rivas, Ana
AB In this study, we aimed to clarify the effects of phenolic compounds and extracts from different extra virgin olive oil (EVOO) varieties obtained from fruits of different ripening stages on osteoblast cells (MG-63) proliferation. Cell proliferation was increased by hydroxytyrosol, luteolin, apigenin, p-coumaric, caffeic, and ferulic acids by approximately 11-16%, as compared with controls that were treated with one vehicle alone, while (+)-pinoresinol, oleuropein, sinapic, vanillic acid and derivative (vanillin) did not affect cell proliferation. All phenolic extracts stimulated MG-63 cell growth, and they induced higher cell proliferation rates than individual compounds. The most effective EVOO phenolic extracts were those obtained from the Picual variety, as they significantly increased cell proliferation by 18-22%. Conversely, Arbequina phenolic extracts increased cell proliferation by 9-13%. A decline in osteoblast proliferation was observed in oils obtained from olive fruits collected at the end of the harvest period, as their total phenolic content decreases at this late stage. Further research on the signaling pathways of olive oil phenolic compounds involved in the processes and their metabolism should be carried out to develop new interventions and adjuvant therapies using EVOO for bone health (i.e.osteoporosis) in adulthood and the elderly.
YR 2016
FD 2016-03-01
LK http://hdl.handle.net/10668/9881
UL http://hdl.handle.net/10668/9881
LA en
DS RISalud
RD Apr 10, 2025