RT Journal Article
T1 Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study).
A1 Talavera-Garcia, Eva
A1 Delgado-Lista, Javier
A1 Garcia-Rios, Antonio
A1 Delgado-Casado, Nieves
A1 Gomez-Luna, Purificacion
A1 Gomez-Garduño, Angela
A1 Gomez-Delgado, Francisco
A1 Alcala-Diaz, Juan F
A1 Yubero-Serrano, Elena
A1 Marin, Carmen
A1 Perez-Caballero, Ana I
A1 Fuentes-Jimenez, Francisco J
A1 Camargo, Antonio
A1 Rodriguez-Cantalejo, Fernando
A1 Tinahones, Francisco J
A1 Ordovas, Jose M
A1 Perez-Jimenez, Francisco
A1 Perez-Martinez, Pablo
A1 Lopez-Miranda, Jose
K1 Adult
K1 Aged
K1 Body mass index
K1 Body weight
K1 Carotid artery diseases
K1 Carotid intima-media thickness
AB Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence of isolated overweight and obesity on carotid intima media thickness (IMT-CC), and also assessed whether this influence was determined by the presence of metabolic abnormalities. 1002 participants from the CordioPrev study were studied at entry. We determined their metabolic phenotypes and performed carotid ultrasound assessment. We evaluated the influence of obesity, overweight and metabolic phenotypes on the IMT-CC. Metabolically sick participants (defined by the presence of two or more metabolic abnormalities) showed a greater IMT-CC than metabolically healthy individuals (p = 4 * 10(-6)). Overweight and normal weight patients who were metabolically healthy showed a lower IMT-CC than the metabolically abnormal groups (all p In coronary patients, a metabolically abnormal phenotype is associated with a greater IMT-CC, and may be linked to a higher risk of suffering new cardiovascular events. The protection conferred in the IMT-CC by the absence of metabolic abnormality may be blunted by the presence of obesity. 
PB Public Library os Science
YR 2016
FD 2016-03-23
LK http://hdl.handle.net/10668/9982
UL http://hdl.handle.net/10668/9982
LA en
NO Talavera-Garcia E, Delgado-Lista J, Garcia-Rios A, Delgado-Casado N, Gomez-Luna P, Gomez-Garduño A, et al. Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study). PLoS One. 2016 Apr 11;11(4):e0153096
DS RISalud
RD Apr 7, 2025