RT Journal Article
T1 Skin Phototype Could Be a Risk Factor for Multiple Sclerosis.
A1 Urbaneja, Patricia
A1 Hurtado-Guerrero, Isaac
A1 Hernández, Miguel Ángel
A1 Oliver-Martos, Begoña
A1 Oreja-Guevara, Celia
A1 Ortega-Pinazo, Jesús
A1 Alonso, Ana
A1 Barón-López, Francisco J
A1 Leyva, Laura
A1 Fernández, Óscar
A1 Pinto-Medel, María Jesús
K1 HLA
K1 multiple sclerosis
K1 skin phototypes
K1 smoking
K1 vitamin D
AB Environmental and genetic factors are assumed to be necessary for the development of multiple sclerosis (MS), however its interactions are still unclear. For this reason here, we have not only analyzed the impact on increased risk of MS of the best known factors (HLA-DRB1*15:01 allele, sun exposure, vitamin D levels, smoking habit), but we have included another factor (skin phototype) that has not been analyzed in depth until now. This study included 149 MS patients and 147 controls. A multivariate logistic regression (LR) model was carried out to determine the impact of each of the factors on the increased risk of MS. Receiver Operating Characteristics (ROC) analysis was performed to evaluate predictive value of the models. Our multifactorial LR model of susceptibility showed that females with light brown skin (LBS), smokers and who had HLA-DRB1*15:01 allele had a higher MS risk (LBS: OR = 5.90, IC95% = 2.39-15.45; smoker: OR = 4.52, IC95% = 2.69-7.72; presence of HLA-DRB1*15:01: OR = 2.39, IC95% = 1.30-4.50; female: OR = 1.88, IC95% = 1.08-3.30). This model had an acceptable discriminant value with an Area Under a Curve AUC of 0.76 (0.69-0.82). Our study indicates that MS risk is determined by complex interactions between sex, environmental factors, and genotype where the milieu could provide the enabling proinflammatory environment that drives an autoimmune attack against myelin by self-reactive lymphocytes.
SN 2077-0383
YR 2020
FD 2020-07-26
LK https://hdl.handle.net/10668/26156
UL https://hdl.handle.net/10668/26156
LA en
DS RISalud
RD Apr 6, 2025