RT Journal Article
T1 Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model.
A1 Escribano, Begoña M
A1 Medina-Fernandez, Francisco J
A1 Aguilar-Luque, Macarena
A1 Agüera, Eduardo
A1 Feijoo, Montserrat
A1 Garcia-Maceira, Fe I
A1 Lillo, Rafael
A1 Vieyra-Reyes, Patricia
A1 Giraldo, Ana I
A1 Luque, Evelio
A1 Drucker-Colin, Rene
A1 Tunez, Isaac
K1 Dimethyl fumarate
K1 Experimental autoimmune encephalomyelitis
K1 Lipopolysaccharide binding protein
K1 Natalizumab
K1 Oxidative stress
K1 Relapsing-remitting multiple sclerosis
AB Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that altering certain bacterial populations present in the gut may lead to a proinflammatory condition, that could result in the development of multiple sclerosis (MS). Also, Reactive Oxygen Species seem to be involved in the course of MS. In this study, it has been aimed to relate all these variables starting from an analysis of the lipopolysaccharide (LPS) and LPS-binding protein (LBP) with the determination of parameters related to oxidative stress in the blood, brain and spinal cord. For this purpose, samples obtained from EAE rats and relapsing-remitting (RRMS) MS patients were used. In addition, EAE rats were treated with Natalizumab, N-acetyl-cysteine and dimethyl fumarate. Natalizumab was also employed in RRMS. The results of this study revealed an improvement in the clinical symptoms of the EAE and MS with the treatments, as well as a reduction in the oxidative stress parameters and in LBP. Correlations between the clinical variables of the disease, i.e. oxidative damage and LBP, were established. Although the conclusions of this research are indeed relevant, further investigation would be necessary to establish the intrinsic mechanisms of the MS-oxidative stress-microbiota relationship.
PB Elsevier
YR 2017
FD 2017
LK http://hdl.handle.net/10668/10518
UL http://hdl.handle.net/10668/10518
LA en
NO Escribano BM, Medina-Fernández FJ, Aguilar-Luque M, Agüera E, Feijoo M, Garcia-Maceira FI, et al. Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model. Neurotherapeutics. 2017 Jan;14(1):199-211
DS RISalud
RD Apr 11, 2025