RT Journal Article
T1 Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity.
A1 Fleury Curado, Thomaz
A1 Pho, Huy
A1 Berger, Slava
A1 Caballero-Eraso, Candela
A1 Shin, Mi-Kyung
A1 Sennes, Luiz Ubirajara
A1 Pham, Luu
A1 Schwartz, Alan R
A1 Polotsky, Vsevolod Y
AB Obesity leads to sleep-disordered breathing (SDB) manifested by recurrent upper airway obstructions termed obstructive sleep apnea (OSA) and carbon dioxide retention due to hypoventilation. The objective of this work was to characterize breathing during sleep in C57BL6/J mice with diet-induced obesity (DIO). Arterial blood gas was measured in nine obese and nine lean mice during wakefulness. Nine male mice with DIO and six lean male C57BL/6J mice were head mounted with electroencephalogram (EEG) and electromyogram (EMG) electrodes. Sleep recordings were performed in the whole body plethysmography chamber; upper airway obstruction was characterized by the presence of inspiratory flow limitation in which airflow plateaus with increases in inspiratory effort. Obese mice showed significantly lower pH and higher partial pressure of arterial CO2 (PaCO2) in arterial blood gas compared to lean mice, 7.35 ± 0.04 versus 7.46 ± 0.06 (p
YR 2018
FD 2018
LK http://hdl.handle.net/10668/12475
UL http://hdl.handle.net/10668/12475
LA en
DS RISalud
RD Apr 12, 2025