TY - JOUR AU - Perez, Ana Belen AU - Chueca, Natalia AU - Macias, Juan AU - Pineda, Juan Antonio AU - Salmeron, Javier AU - Rivero-Juarez, Antonio AU - Hidalgo-Tenorio, Carmen AU - Espinosa, Maria Dolores AU - Tellez, Francisco AU - Von-Wichmann, Miguel Angel AU - Omar, Mohamed AU - Santos, Jesus AU - Hernandez-Quero, Jose AU - Anton, Jose Joaquin AU - Collado, Antonio AU - Lozano, Ana Belen AU - Garcia-Deltoro, Miguel AU - Casado, Marta AU - Pascasio, Juan Manuel AU - Selfa, Aida AU - Rosales, Jose Miguel AU - De la Iglesia, Alberto AU - Arenas, Juan Ignacio AU - Garcia-Bujalance, Silvia AU - Rios, Maria Jose AU - Bernal, Enrique AU - Martinez, Onofre AU - Garcia-Herola, Antonio AU - Velez, Monica AU - Rincon, Pilar AU - Garcia, Federico PY - 2019 DO - 10.1371/journal.pone.0221231 UR - http://hdl.handle.net/10668/14460 T2 - PloS one AB - Treatment guidelines differ in their recommendation to determine baseline resistance associated substitutions (RAS) before starting a first-line treatment with direct-acting antivirals (DAAs). Here we analyze the efficacy of DAA treatment with... LA - en PB - Public Library of Science KW - Área de Gestión Sanitaria Sur de Granada KW - Área de Gestión Sanitaria Sur de Sevilla KW - Amides KW - Antiviral agents KW - Benzofurans KW - Carbamates KW - Cyclopropanes KW - Drug resistance, viral KW - Female KW - Genotype KW - Hepacivirus KW - Hepatitis C, chronic KW - Humans KW - Imidazoles KW - Male KW - Middle aged KW - Mutation KW - Quinoxalines KW - Ribavirin KW - Sofosbuvir KW - Spain KW - Sulfonamides KW - Sustained virologic response KW - Viral nonstructural proteins TI - Prevalence of resistance associated substitutions and efficacy of baseline resistance-guided chronic hepatitis C treatment in Spain from the GEHEP-004 cohort. TY - research article VL - 14 ER -