RT Journal Article
T1 Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.
A1 Kong, So Yeon
A1 Tran, Hao Quang
A1 Gewirtz, Andrew T
A1 McKeown-Eyssen, Gail
A1 Fedirko, Veronika
A1 Romieu, Isabelle
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Bastide, Nadia
A1 Affret, Aurélie
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Boeing, Heiner
A1 Aleksandrova, Krasimira
A1 Trichopoulou, Antonia
A1 Kritikou, Maria
A1 Vasilopoulou, Effie
A1 Palli, Domenico
A1 Krogh, Vittorio
A1 Mattiello, Amalia
A1 Tumino, Rosario
A1 Naccarati, Alessio
A1 Bueno-de-Mesquita, H B
A1 Peeters, Petra H
A1 Weiderpass, Elisabete
A1 Quirós, J Ramón
A1 Sala, Núria
A1 Sanchez-Perez, Maria-Jose
A1 Castaño, José María Huerta
A1 Barricarte, Aurelio
A1 Dorronsoro, Miren
A1 Werner, Mårten
A1 Wareham, Nicholas J
A1 Khaw, Kay-Tee
A1 Bradbury, Kathryn E
A1 Freisling, Heinz
A1 Stavropoulou, Faidra
A1 Ferrari, Pietro
A1 Gunter, Marc J
A1 Cross, Amanda J
A1 Riboli, Elio
A1 Bruce, W Robert
A1 Jenab, Mazda
AB Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody levels and colorectal cancer risk. A total of 1,065 incident colorectal cancer cases (colon, n = 667; rectal, n = 398) were matched (1:1) to control subjects. Serum flagellin- and LPS-specific IgA and IgG levels were quantitated by ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (CI), adjusting for multiple relevant confouding factors. Overall, elevated anti-LPS and anti-flagellin biomarker levels were not associated with colorectal cancer risk. After testing potential interactions by various factors relevant for colorectal cancer risk and anti-LPS and anti-flagellin, sex was identified as a statistically significant interaction factor (Pinteraction  In this prospective study on European populations, we found bacterial exposure levels to be positively associated to colorectal cancer risk among men, whereas in women, a possible inverse association may exist. Further studies are warranted to better clarify these preliminary observations.
YR 2016
FD 2016-01-11
LK http://hdl.handle.net/10668/9789
UL http://hdl.handle.net/10668/9789
LA en
DS RISalud
RD Apr 10, 2025