RT Generic
T1 Should workers be physically active after work? Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels-An individual participant data meta-analysis.
A1 Cillekens, Bart
A1 Coenen, Pieter
A1 Huysmans, Maaike A
A1 Holtermann, Andreas
A1 Troiano, Richard P
A1 Mork, Paul Jarle
A1 Krokstad, Steinar
A1 Clays, Els
A1 De Bacquer, Dirk
A1 Aadahl, Mette
A1 Kårhus, Line Lund
A1 Sjøl, Anette
A1 Bo Andersen, Lars
A1 Kauhanen, Jussi
A1 Voutilainen, Ari
A1 Pulsford, Richard
A1 Stamatakis, Emmanuel
A1 Goldbourt, Uri
A1 Peters, Annette
A1 Thorand, Barbara
A1 Rosengren, Annika
A1 Björck, Lena
A1 Sprow, Kyle
A1 Franzon, Kristin
A1 Rodriguez-Barranco, Miguel
A1 Luján-Barroso, Leila
A1 Alfredsson, Lars
A1 Bahls, Martin
A1 Ittermann, Till
A1 Wanner, Miriam
A1 Bopp, Matthias
A1 Marott, Jacob Louis
A1 Schnohr, Peter
A1 Nordestgaard, Børge G
A1 Dalene, Knut Eirik
A1 Ekelund, Ulf
A1 Clausen, Johan
A1 Jensen, Magnus T
A1 Petersen, Christina Bjørk
A1 Krause, Niklas
A1 Twisk, Jos
A1 van Mechelen, Willem
A1 van der Beek, Allard J
K1 Individual participant data
K1 Job demands
K1 Mortality
K1 Physical activity paradox
AB Background: There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels. This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods: This study utilized individual participant data from 21 cohort studies, comprising both published and unpublished data. Eligibility criteria included individual-level data on leisure-time and occupational physical activity (categorized as sedentary, low, moderate, and high) along with data on all-cause and/or cardiovascular mortality. A 2-stage individual participant data meta-analysis was conducted, with separate analysis of each study using Cox proportional hazards models (Stage 1). These results were combined using random-effects models (Stage 2).Results: Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels, for both males and females. Among males with sedentary work, high compared to sedentary leisure-time physical activity was associated with lower all-cause (hazard ratios (HR) = 0.77, 95% Confidence interval(95%CI): 0.70-0.85) and cardiovascular mortality (HR = 0.76, 95%CI: 0.66-0.87) risk. Among males with high levels of occupational physical activity, high compared to sedentary leisure-time physical activity was associated with lower all-cause (HR = 0.84, 95%CI: 0.74-0.97) and cardiovascular mortality (HR = 0.79, 95%CI: 0.60-1.04) risk, while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant. Among females, most effects were similar but more imprecise, especially in the higher occupational physical activity levels.Conclusion: Higher levels of leisure-time physical activity were generally associated with lower mortality risks. However, results for workers with moderate and high occupational physical activity levels, especially women, were more imprecise. Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity, irrespective of their level of occupational physical activity.
PB Shanghai University of Sport
YR 2024
FD 2024-09-12
LK https://hdl.handle.net/10668/24325
UL https://hdl.handle.net/10668/24325
LA en
NO Cillekens B, Coenen P, Huysmans MA, Holtermann A, Troiano RP, Mork PJ, et al. Should workers be physically active after work? Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels-An individual participant data meta-analysis. J Sport Health Sci. 2024 Sep 12:100987.
NO Data and/or sample material have been provided by the Study of Health in Pomerania (SHIP) from the Community Medicine Research Alliance of the University Medicine Greifswald. The Trøndelag Health Study (HUNT) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology), Trøndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public Health. The coordination of EPIC is financially supported by the International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The EPIC cohort is supported by Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucıa, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain). The Kupio Ischemic Heart Disease Risk Factor (KIHD) study data were provided by the University of Eastern Finland. The Active Worker study was funded by The Netherlands Organisation for Health Research and Development; ZonMw (Grant No.: 531-00141-3). Funding for the SHIP study has been provided by the Federal Ministry for Education and Research (BMBF; identification codes 01 ZZ96030, 01 ZZ0103 and 01 ZZ0701). The Primary Prevention study received support from the Swedish Research Council (2018-02527 and 2019-00193). The MONICA/KORA Augsburg study was initiated and financed by the Helmholtz Zentrum M€unchen  German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria
DS RISalud
RD Apr 19, 2025