TY - JOUR AU - Malmierca, Mónica G AU - Pérez-Victoria, Ignacio AU - Martín, Jesús AU - Reyes, Fernando AU - Méndez, Carmen AU - Salas, José A AU - Olano, Carlos PY - 2020 DO - 10.1128/AEM.02453-19 UR - http://hdl.handle.net/10668/14698 T2 - Applied and environmental microbiology AB - The appearance of new infectious diseases, the increase in multidrug-resistant bacteria, and the need for more effective chemotherapeutic agents have oriented the interests of researchers toward the search for metabolites with novel or improved... LA - en KW - Streptomyces KW - combinatorial biosynthesis KW - glycosylation KW - Bacterial Proteins KW - Biosynthetic Pathways KW - Genes, Bacterial KW - Glycosylation KW - Glycosyltransferases KW - Lactams KW - Multigene Family KW - Mutation KW - Streptomyces TI - New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway. TY - research article VL - 86 ER -