RT Journal Article
T1 Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae.
A1 Fernández-Pastor, Ignacio
A1 González-Menéndez, Victor
A1 Annang, Frederick
A1 Toro, Clara
A1 Mackenzie, Thomas A
A1 Bosch-Navarrete, Cristina
A1 Genilloud, Olga
A1 Reyes, Fernando
K1 Marfey’s analysis
K1 Nigrospora oryzae
K1 antiparasitic activity
K1 fungal endophyte
K1 pipecolisporin
K1 structural elucidation
AB A novel cyclic antimalarial and antitrypanosome hexapeptide, pipecolisporin (1), was isolated from cultures of Nigrospora oryzae CF-298113, a fungal endophyte isolated from roots of Triticum sp. collected in a traditional agricultural land of Montefrío, Granada, Spain. The structure of this compound, including its absolute configuration, was elucidated by HRMS, 1-D and 2-D NMR spectroscopy, and Marfey's analysis. This metabolite displayed interesting activity against Plasmodium falciparum and Trypanosoma cruzi, with IC50 values in the micromolar range, and no significant cytotoxicity against the human cancer cell lines A549, A2058, MCF7, MIA PaCa-2, and HepG2.
SN 1424-8247
YR 2021
FD 2021-03-16
LK http://hdl.handle.net/10668/17514
UL http://hdl.handle.net/10668/17514
LA en
DS RISalud
RD Apr 6, 2025