RT Journal Article
T1 Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study.
A1 Sánchez-Luna, Manuel
A1 Medrano, Constancio
A1 Lirio, Julián
A1 RISK-21 Study Group, 
K1 Down syndrome
K1 hospitalization
K1 palivizumab
K1 prospective birth cohort study
K1 respiratory syncytial virus
AB Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season. The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non-DS cohort (44.1% vs 7.7%, P Infants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non-DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.
YR 2016
FD 2016-12-30
LK https://hdl.handle.net/10668/24972
UL https://hdl.handle.net/10668/24972
LA en
DS RISalud
RD Apr 6, 2025