RT Journal Article
T1 Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?
A1 de la Rubia Ortí, Jose Enrique
A1 Platero Armero, Jose Luis
A1 Sanchis-Sanchis, Claudia Emmanuela
A1 Sancho-Castillo, Sandra
A1 Salazar, Alejandro
A1 Caplliure-Llopis, Jordi
A1 Navarro-Illana, Esther
A1 Barrios, Carlos
A1 Escribá-Alepuz, Jesús
A1 Benlloch, María
K1 Amyotrophic lateral sclerosis
K1 Glucose
K1 Alkaline phosphatase
K1 Spinal onset ALS
K1 Bulbar onset ALS
K1 Insulin resistance
K1 Muscle strength
K1 Esclerosis amiotrófica lateral
K1 Glucosa
K1 Fosfatasa alcalina
K1 Atrofia muscular espinal
K1 Esclerosis amiotrófica lateral
K1 Resistencia a la insulina
K1 Fuerza muscular
AB Background: One of the pathogenic mechanisms of ALS disease is perturbed energy metabolism particularly glucose metabolism. Given the substantial difference in the severity and the prognosis of the disease, depending on whether it has a bulbar or spinal onset, the aim of the study was to determine metabolic differences between both types of ALS, as well as the possible relationship with muscle function. Materials and Methods: A descriptive, analytical, quantitative, and transversal study was carried out in hospitals and Primary Care centers in the region of Valencia, Spain. Fasting glucose and alkaline phosphatase (AP) levels in venous blood, muscle percentage, fat percentage, muscle strength (MRC scale), and functional capacity (Barthel Index) were measured in 31 patients diagnosed with ALS (20 with spinal onset ALS and 11 with bulbar onset ALS). A healthy control of 29 people was included. Results: No significant differences were observed in blood AP and glucose levels between spinal onset and bulbar onset ALS patients. However, a significant positive correlation was observed between the mean values of both substances in patients with spinal onset ALS. Moreover, a lower percentage of muscle mass and a higher percentage of fat mass were also seen in spinal ALS patients, who also presented lower muscle strength and lower functional capacity. Conclusion: The results of this study seem to point to a possible difference in the peripheral use of glucose between patients with bulbar onset ALS and spinal onset ALS, who appear to have possible insulin resistance. These metabolic differences could explain the lower muscle percentage and lower muscular function in spinal onset ALS patients, although further studies are required.
PB MDPI
YR 2021
FD 2021-04-09
LK http://hdl.handle.net/10668/4504
UL http://hdl.handle.net/10668/4504
LA en
NO de la Rubia Ortí JE, Armero JLP, Sanchis-Sanchis CE, Sancho-Castillo S, Salazar A, Caplliure-Llopis J, et al. Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose? J Clin Med. 2021 Apr 9;10(8):1582
DS RISalud
RD Apr 11, 2025