RT Journal Article
T1 A Systematic Review and Meta-Analysis of Advanced Biomarkers for Predicting Incident Cardiovascular Disease among Asymptomatic Middle-Aged Adults.
A1 Romero-Cabrera, Juan Luis
A1 Ankeny, Jacob
A1 Fernandez-Montero, Alejandro
A1 Kales, Stefanos N
A1 Smith, Denise L
K1 Atherosclerosis
K1 Biomarkers
K1 Coronary artery disease
K1 Inflammation
K1 Prediction
K1 Screening
AB Cardiovascular disease (CVD) continues as the most important cause of mortality. Better risk screening and prediction are needed to reduce the cardiovascular disease burden. The aim of the study was to assess the role of serum biomarkers in the prediction of CVD among asymptomatic middle-aged adults with no prior CVD history. A systematic review and meta-analysis were carried out using literature from PubMed and following PRISMA reporting guidelines. Twenty-five studies met our inclusion criteria and were included in the systematic review. The most commonly studied biomarker was high-sensitivity C reactive protein (hs-CRP) (10 studies), which showed that higher hs-CRP levels are associated with an increased risk of subsequent CVD events and mortality. In addition, several less-studied biomarkers (N-terminal pro-brain natriuretic peptide (NT-proBNP), fibrinogen, gamma-glutamyl transferase (GGT), and others) also showed significant associations with greater future risk of CVD. A meta-analysis was possible to perform for hs-CRP and NT-proBNP, which showed statistically significant results for the ability of hs-CRP (hazard ratio (HR) 1.19, (95% CI: 1.09−1.30), p< 0.05) and NT-proBNP (HR 1.22, (1.13–1.32), p < 0.05) to predict incident CVD among middle-aged adults without a prior CVD history or symptoms. Several serum biomarkers, particularly hs-CRP and NT-proBNP, have the potential to improve primary CVD risk prevention among asymptomatic middle-aged adults 
PB MDPI
YR 2022
FD 2022-10-30
LK http://hdl.handle.net/10668/21212
UL http://hdl.handle.net/10668/21212
LA en
NO Romero-Cabrera JL, Ankeny J, Fernández-Montero A, Kales SN, Smith DL. A Systematic Review and Meta-Analysis of Advanced Biomarkers for Predicting Incident Cardiovascular Disease among Asymptomatic Middle-Aged Adults. Int J Mol Sci. 2022 Nov 4;23(21):13540
DS RISalud
RD Apr 8, 2025