RT Generic
T1 Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays
A1 Leuermann, Jonas
A1 Stamenkovic, Vladimir
A1 Ramirez-Priego, Patricia
A1 Sánchez-Postigo, Alejandro
A1 Fernández-Gavela, Adrián
A1 Chapman, Cole A.
A1 Bailey, Ryan C.
A1 Lechuga, Laura M.
A1 Perez-Inestrosa, Ezequiel
A1 Collado, Daniel
A1 Halir, Robert
A1 Molina-Fernández, Íñigo
K1 Photons
K1 Fotones
K1 Biosensing techniques
K1 Técnicas biosensibles
K1 Lasers
K1 Rayos laser
K1 Interferometry
K1 Interferometría
K1 C-Reactive Protein
K1 Proteína C-Reactiva
K1 Limit of detection
K1 Límite de detección
K1 Immunoassay
K1 Inmunoensayo
AB Over the past two decades, integrated photonic sensors have been of major interest to the optical biosensor community due to their capability to detect low concentrations of molecules with label-free operation. Among these, interferometric sensors can be read-out with simple, fixed-wavelength laser sources and offer excellent detection limits but can suffer from sensitivity fading when not tuned to their quadrature point. Recently, coherently detected sensors were demonstrated as an attractive alternative to overcome this limitation. Here we show, for the first time, to the best of our knowledge, that this coherent scheme provides sub-nanogram per milliliter limits of detection in C-reactive protein immunoassays and that quasi-balanced optical arm lengths enable operation with inexpensive Fabry-Perot-type lasers sources at telecom wavelengths.
PB Optical Society of America
SN 0146-9592
YR 2020
FD 2020-12-08
LK http://hdl.handle.net/10668/3374
UL http://hdl.handle.net/10668/3374
LA spa
NO Leuermann J, Stamenkovic V, Ramirez-Priego P, Sánchez-Postigo A, Fernández-Gavela A, Chapman CA, et al. Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays. Opt Lett. 2020 Dec 8;45(24):6595-6598.
DS RISalud
RD Apr 6, 2025