RT Journal Article
T1 [Use of absorbable fibrin sealant patch to strengthen the gastrointestinal anastomosis performed on patients with peritoneal carcinomatosis treated with intention to cure by debulking surgery and intraoperative hyperthermic intraperitoneal chemotherapy].
T2 Aplicación de sellante tisular como refuerzo de las anastomosis digestivas realizadas en pacientes con carcinomatosis peritoneal tratados con intención curativa mediante procedimiento quirúrgico de citorreducción y quimioterapia intraperitoneal intraoperatoria hipertérmica.
A1 Torres-Melero, Juan
A1 Motos-Micó, José Jacob
A1 Lorenzo-Liñán, Miguel
A1 Morales-González, Álvaro
A1 Rosado-Cobián, Rafael
K1 Absorbable fibrin sealant patch
K1 Anastomosis intestinal
K1 Carcinomatosis
K1 Cirugía citorreductora
K1 Debulking surgery
K1 Esponja de colágeno con fibrinógeno
K1 Intestinal anastomosis
AB Peritoneal disseminated disease, regardless of its origin, should currently be considered a locoregional disease stage, and thus a candidate for an intention to treat therapeutic option with debulking surgery and hyperthermic intraperitoneal chemotherapy. To determine whether or not the collagen sponge with fibrinogen 5.5mg and thrombin 2IU, applied as a tissue sealant and gastrointestinal reinforcement sutures, contributes to the reduction of anastomotic leak. Quasi-experimental, comparative, prospective, case/control study conducted on patients with peritoneal carcinomatosis of colorectal origin, operated on in our Peritoneal Cancer Surgery Unit from 2011 to April 2014. The study included 73 patients, 43 (59%) men and 30 (41%) women with peritoneal carcinomatosis of colorectal origin, candidates for debulking surgery and hyperthermic intraperitoneal chemotherapy. Gastrointestinal anastomoses were performed on 49 (67%) patients. These patients were randomised into 2 groups: A control (27) and B hypothesis (22) reinforced with sponge suture. The total number of anastomoses performed was 49 (mean: 1.9), with 27 in the control group A (mean: 1.88) and 22 in B (mean: 2.16). The debulkings achieved were: complete debulking 0.38 (77.5%), complete debulking 1: 7 (14.8%), and 4 (8.1%) did not undergo hyperthermic intraperitoneal chemotherapy due to complete debulking>2. Intestinal fistula: 3 cases (6.1%) in A group vs 0 in B. In our series, the use of a fibrinogen and thrombin sponge has contributed to a significant reduction in the risk of gastrointestinal fistulas in high risk oncology patients.
YR 2016
FD 2016-01-14
LK http://hdl.handle.net/10668/9742
UL http://hdl.handle.net/10668/9742
LA es
DS RISalud
RD Apr 19, 2025