RT Journal Article
T1 A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women.
A1 Pastor, Antoni
A1 Fernández-Aranda, Fernando
A1 Fitó, Montserrat
A1 Jiménez-Murcia, Susana
A1 Botella, Cristina
A1 Fernández-Real, José M
A1 Frühbeck, Gema
A1 Tinahones, Francisco J
A1 Fagundo, Ana B
A1 Rodríguez, Joan
A1 Agüera, Zaida
A1 Langohr, Klaus
A1 Casanueva, Felipe F
A1 Torre, Rafael de la
K1 Tejido adiposo
K1 Obesidad mórbida
K1 Índice de masa corporal
K1 Endocannabinoides
K1 Ácidos araquidónicos
K1 Anticonceptivos
K1 Olores
K1 Olfato
K1 Hábito de fumar
K1 Etanolaminas
K1 Humanos
K1 Gato
K1 Femenino
AB The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in a human sample that includes people with obesity and explore the possible interaction between olfaction, obesity and the eCB system. The study sample was made up of 161 females with five groups of body mass index sub-categories ranging from under-weight to morbidly obese. We assessed olfactory capacity with the "Sniffin´Sticks" test, which measures olfactory threshold-discrimination-identification (TDI) capacity. We measured plasma concentrations of the eCBs 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine or anandamide (AEA), and several eCB-related compounds, 2-acylglycerols and N-acylethanolamines. 2-AG and other 2-acylglycerols fasting plasma circulating plasma concentrations were higher in obese and morbidly obese subjects. AEA and other N-acylethanolamine circulating concentrations were lower in under-weight subjects. Olfactory TDI scores were lower in obese and morbidly obese subjects. Lower TDI scores were independently associated with higher 2-AG fasting plasma circulating concentrations, higher %body fat, and higher body mass index, after controlling for age, smoking, menstruation, and use of contraceptives. Our results show that obese subjects have a lower olfactory capacity than non-obese ones and that elevated fasting plasma circulating 2-AG concentrations in obesity are linked to a lower olfactory capacity. In agreement with previous studies we show that eCBs AEA and 2-AG, and their respective congeners have a distinct profile in relation to body mass index. The present report is the first study in humans in which olfactory capacity and circulating eCB concentrations have been measured in the same subjects.
PB Public Library of Science
YR 2016
FD 2016-02-05
LK http://hdl.handle.net/10668/2171
UL http://hdl.handle.net/10668/2171
LA en
NO Pastor A, Fernández-Aranda F, Fitó M, Jiménez-Murcia S, Botella C, Fernández-Real JM, et al. A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. PLoS ONE. 2016; 11(2):e0148734
NO Journal Article;
DS RISalud
RD Apr 10, 2025