RT Journal Article
T1 Transcriptomic analysis reveals an association of FCGBP with Parkinson's disease.
A1 Gómez-Garre, Pilar
A1 Periñán, María Teresa
A1 Jesús, Silvia
A1 Bacalini, Maria Giulia
A1 Garagnani, Paolo
A1 Mollenhauer, Brit
A1 Pirazzini, Chiara
A1 Provini, Federica
A1 Trenkwalder, Claudia
A1 Franceschi, Claudio
A1 Mir, Pablo
A1 PROPAG-AGEING consortium, 
AB Transcriptomics in Parkinson's disease (PD) offers new insights into the molecular mechanism of PD pathogenesis. Several pathways, such as inflammation and protein degradation, have been identified by differential gene expression analysis. Our aim was to identify gene expression differences underlying the disease etiology and the discovery of pre-symptomatic risk biomarkers for PD from a multicenter study in the context of the PROPAG-AGEING project. We performed RNA sequencing from 47 patients with de novo PD, 10 centenarians, and 65 healthy controls. Using identified differentially expressed genes, functional annotations were assigned using gene ontology to unveil significant enriched biological processes. The expression of 16 selected genes was validated using OpenArray® assays and samples from independent cohorts of 201 patients with advanced PD, 340 healthy siblings of PD patients, and 177 healthy controls. Differential gene expression analysis identified higher FCGBP expression in patients with de novo PD compared with healthy controls and compared with centenarians. Furthermore, FCGBP showed no differences in terms of population origin or aging process. The increased FCGBP expression was validated in patients with advanced PD and their siblings. Thus, we provided evidence for an upregulation of FCGBP mRNA levels not only in patients with PD but also in individuals at putative higher risk of PD, suggesting that it could be important in gut-brain PD interaction, mediating the connection between microbiota and intestinal inflammatory processes, as well as neuroinflammation and neurodegeneration.
SN 2373-8057
YR 2022
FD 2022-11-12
LK http://hdl.handle.net/10668/19557
UL http://hdl.handle.net/10668/19557
LA en
DS RISalud
RD Apr 7, 2025