RT Generic
T1 Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review
A1 Toledano-Osorio, Manuel
A1 Vallecillo, Cristina
A1 Vallecillo-Rivas, Marta
A1 Manzano-Moreno, Francisco-Javier
A1 Osorio, Raquel
K1 barrier membrane
K1 polymer
K1 collagen
K1 antibiotic
K1 bone regeneration
K1 Tissue regeneration
K1 Bone regeneration
K1 Antibacterial efficacy
K1 Bacterial adhesion
K1 Collagen membrane
K1 Tetracycline
K1 Release
K1 Metronidazole
K1 Defects
K1 Attachment
AB Polymeric membranes are frequently used for bone regeneration in oral and periodontal surgery. Polymers provide adequate mechanical properties (i.e., Young's modulus) to support oral function and also pose some porosity with interconnectivity to permit for cell proliferation and migration. Bacterial contamination of the membrane is an event that may lead to infection at the bone site, hindering the clinical outcomes of the regeneration procedure. Therefore, polymeric membranes have been proposed as carriers for local antibiotic therapy. A literature search was performed for papers, including peer-reviewed publications. Among the different membranes, collagen is the most employed biomaterial. Collagen membranes and expanded polytetrafluoroethylene loaded with tetracyclines, and polycaprolactone with metronidazole are the combinations that have been assayed the most. Antibiotic liberation is produced in two phases. A first burst release is sometimes followed by a sustained liberation lasting from 7 to 28 days. All tested combinations of membranes and antibiotics provoke an antibacterial effect, but most of the time, they were measured against single bacteria cultures and usually non-specific pathogenic bacteria were employed, limiting the clinical relevance of the attained results. The majority of the studies on animal models state a beneficial effect of these antibiotic functionalized membranes, but human clinical assays are scarce and controversial.
PB MDPI AG
YR 2022
FD 2022-02-14
LK http://hdl.handle.net/10668/21564
UL http://hdl.handle.net/10668/21564
LA en
NO Toledano-Osorio M, Vallecillo C, Vallecillo-Rivas M, Manzano-Moreno FJ, Osorio R. Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review. Polymers (Basel). 2022 Feb 21;14(4):840.
DS RISalud
RD Apr 8, 2025