RT Journal Article
T1 Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status.
A1 López-Mejías, Raquel
A1 Genre, Fernanda
A1 Sevilla Pérez, Belén
A1 Castañeda, Santos
A1 Ortego-Centeno, Norberto
A1 Llorca, Javier
A1 Ubilla, Begoña
A1 Remuzgo-Martínez, Sara
A1 Mijares, Verónica
A1 Pina, Trinitario
A1 Calvo-Río, Vanesa
A1 Márquez, Ana
A1 Miranda-Filloy, José A
A1 Navas Parejo, Antonio
A1 Conde-Jaldón, Marta
A1 Ortiz-Fernández, Lourdes
A1 Argila, Diego
A1 Aragües, Maximiliano
A1 Rubio, Esteban
A1 León Luque, Manuel
A1 Blanco-Madrigal, Juan María
A1 Galíndez-Aguirregoikoa, Eva
A1 González Escribano, Francisca
A1 Ocejo-Vinyals, J Gonzalo
A1 Martín, Javier
A1 Blanco, Ricardo
A1 González-Gay, Miguel A
K1 Adolescente
K1 Niño
K1 Preescolar
K1 Femenino
K1 Estudios de seguimiento
K1 Estudios de asociación genética
K1 Predisposición genética a la enfermedad
K1 Antígenos HLA-B
K1 Cadenas HLA-DRB1
K1 Humanos
K1 Masculino
K1 Púrpura de Schoenlein-Henoch
K1 Adulto joven
K1 España
AB INTRODUCTION:A study was conducted to determine whether the human leukocyte antigen (HLA) B alleles are implicated in the susceptibility to Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies.METHODS:The study population was composed of 349 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria, and 335 sex and ethnically matched controls. HLA-B phenotypes were determined by sequencing-based typing (SBT) and analyzed by chi-square or Fisher exact test.RESULTS:A statistically significant increase of HLA-B*41:02 allele in HSP patients when compared with controls was found (8.3% versus 1.5% respectively; P = 0.0001; OR (odds ratio) =5.76 [2.15-19.3]). These results remained statistically significant after adjusting for Bonferroni correction (P = 0.0028). An internal validation also confirmed the susceptibility effect on HSP associated with HLA-B*41:02 (OR = 5.70 [1.98-16.44]). Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03. Interestingly, the association remained statistically significant (P = 0.0004, OR = 4.97 [1.8-16.9]). No HLA-B association with specific HSP clinical features was found.CONCLUSIONS:Our study indicates that HLA-B*41:02 is associated with the susceptibility to HSP in Spanish patients irrespective of HLA-DRB1 status.
PB BioMed Central
SN 1478-6354
YR 2015
FD 2015-04-14
LK http://hdl.handle.net/10668/2625
UL http://hdl.handle.net/10668/2625
LA en
NO López-Mejías R, Genre F, Pérez BS, Castañeda S, Ortego-Centeno N, Llorca J, et al. Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status. Arthritis Res. Ther. 2015; 17:102
NO This study was supported by a grant from ‘Fondo de Investigaciones Sanitarias’ PI12/00193 (Spain). RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (Spain) (CD12/00425). FG and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013).
DS RISalud
RD Apr 18, 2025