RT Journal Article
T1 Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD.
A1 Marques, Vanda
A1 Afonso, Marta B
A1 Bierig, Nina
A1 Duarte-Ramos, Filipa
A1 Santos-Laso, Álvaro
A1 Jimenez-Agüero, Raul
A1 Eizaguirre, Emma
A1 Bujanda, Luis
A1 Pareja, Maria J
A1 Luís, Rita
A1 Costa, Adília
A1 Machado, Mariana V
A1 Alonso, Cristina
A1 Arretxe, Enara
A1 Alustiza, José M
A1 Krawczyk, Marcin
A1 Lammert, Frank
A1 Tiniakos, Dina G
A1 Flehmig, Bertram
A1 Cortez-Pinto, Helena
A1 Banales, Jesus M
A1 Castro, Rui E
A1 Normann, Andrea
A1 Rodrigues, Cecília M P
K1 IGF-1
K1 NAFLD
K1 adiponectin
K1 circulating biomarkers
K1 fibrosis
K1 leptin
K1 lipid metabolism
AB Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 serum levels were measured by ELISA in two independent cohorts of biopsy-proven obese NAFLD patients and healthy-liver controls (discovery: 38 NAFLD, 13 controls; validation: 194 NAFLD, 31 controls) and correlated with clinical data, histology, genetic parameters, and serum metabolomics. Results: In both cohorts, leptin increased in NAFLD vs. controls (discovery: AUROC 0.88; validation: AUROC 0.83; p
SN 2296-858X
YR 2021
FD 2021-06-23
LK http://hdl.handle.net/10668/18189
UL http://hdl.handle.net/10668/18189
LA en
DS RISalud
RD Apr 7, 2025