RT Journal Article
T1 Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis.
A1 O'Valle, Francisco
A1 Peregrina, Magdalena
A1 Crespo-Lora, Vicente
A1 Galindo-Moreno, Pablo
A1 Roman, Maria
A1 Padial-Molina, Miguel
A1 Mesa, Francisco
A1 Aneiros-Fernandez, Jose
A1 Aguilar, David
A1 Gonzalez-Rey, Elena
A1 Delgado, Mario
A1 Hernandez-Cortes, Pedro
K1 Modelos teóricos
K1 Artritis experimental
K1 Colágeno tipo II
K1 Ratones
K1 Células madre adultas
K1 Inmunización
K1 Inmunoglobulina g
K1 Articulaciones
K1 Animales
K1 Masculino
K1 Factor de necrosis tumoral alfa
K1 Receptores del factor de necrosis tumoral
AB Background. Collagen-induced arthritis (CIA), a murine experimental disease model induced by immunization with type II collagen (CII), is used to evaluate novel therapeutic strategies for rheumatoid arthritis. Adult stem cell marker Musashi-1 (Msi1) plays an important role in regulating the maintenance and differentiation of stem/precursor cells. The objectives of this investigation were to perform a morphological study of the experimental CIA model, evaluate the effect of TNFα-blocker (etanercept) treatment, and determine the immunohistochemical expression of Msi1 protein. Methods. CIA was induced in 50 male DBA1/J mice for analyses of tissue and serum cytokine; clinical and morphological lesions in limbs; and immunohistochemical expression of Msi1. Results. Clinically, TNFα-blocker treatment attenuated CIA on day 32 after immunization (P < 0.001). Msi1 protein expression was significantly higher in joints damaged by CIA than in those with no lesions (P < 0.0001) and was related to the severity of the lesions (Spearman's rho = 0.775, P = 0.0001). Conclusions. Treatment with etanercept attenuates osteoarticular lesions in the murine CIA model. Osteoarticular expression of Msi1 protein is increased in joints with CIA-induced lesion and absent in nonlesioned joints, suggesting that this protein is expressed when the lesion is produced in order to favor tissue repair.
PB Hindawi Publishing Corporation
YR 2015
FD 2015
LK http://hdl.handle.net/10668/2097
UL http://hdl.handle.net/10668/2097
LA en
NO O'Valle F, Peregrina M, Crespo-Lora V, Galindo-Moreno P, Roman M, Padial-Molina M, et al. Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. Biomed Res Int. 2015:681456
NO Journal Article;
DS RISalud
RD Apr 6, 2025