RT Journal Article
T1 Leveraging Genomics, Transcriptomics, and Epigenomics to Understand the Biology and Chemoresistance of Ovarian Cancer
A1 Muñoz-Galván, Sandra
A1 Carnero, Amancio
K1 Ovarian cancer
K1 Genomics
K1 Transcriptomic
K1 Epigenomics
K1 Chemoresistance
K1 Neoplasias ováricas
K1 Genómica
K1 Epigenómica
K1 Resistencia a antineoplásicos
AB Ovarian cancer is a major cause of fatality due to a gynecological malignancy. This lethality is largely due to the unspecific clinical manifestations of ovarian cancer, which lead to late detection and to high resistance to conventional therapies based on platinum. In recent years, we have advanced our understanding of the mechanisms provoking tumor relapse, and the advent of so-called omics technologies has provided exceptional tools to evaluate molecular mechanisms leading to therapy resistance in ovarian cancer. Here, we review the contribution of genomics, transcriptomics, and epigenomics techniques to our knowledge about the biology and molecular features of ovarian cancers, with a focus on therapy resistance. The use of these technologies to identify molecular markers and mechanisms leading to chemoresistance in these tumors is discussed, as well as potential further applications.
PB MDPI
YR 2021
FD 2021-08-10
LK http://hdl.handle.net/10668/4287
UL http://hdl.handle.net/10668/4287
LA en
NO Muñoz-Galván S, Carnero A. Leveraging Genomics, Transcriptomics, and Epigenomics to Understand the Biology and Chemoresistance of Ovarian Cancer. Cancers. 2021 Aug 10;13(16):4029
DS RISalud
RD Apr 8, 2025