RT Generic
T1 Monoclonal gammopathy of renal significance: Early diagnosis is key
A1 Alonso-Titos, Juana
A1 Dolores Martinez-Esteban, Maria
A1 Lopez, Veronica
A1 Leon, Myriam
A1 Martin-Reyes, Guillermo
A1 Ruiz-Esteban, Pedro
A1 Hernandez, Domingo
K1 Monoclonal gammopathy of renal significance
K1 Monoclonal gammopathy of uncertain significance
K1 Monoclonal gammopathy
K1 Multiple myeloma
K1 Monoclonal immunoglobulin deposition disease
K1 Membranoproliferative glomerulonephritis with monoclonal immunoglobulin deposits
K1 Free light chain
AB Y Monoclonal gammopathy of renal significance is a clinical-pathological entity grouping renal disorders secondary to the secretion of a monoclonal immunoglobulin synthesized by a B-cell-derived clone and/or plasma cells in a patient with no diagnostic criteria for multiple myeloma. This term applies to a concept recently introduced owing to the need to differentiate this entity from monoclonal gammopathy of undetermined significance, given the negative prognostic impact of its high morbidity and mortality resulting from both renal and systemic involvement, occasionally even progressing to advanced chronic kidney disease. The renal damage occurs via both direct pathogenic mechanisms, with the deposition of the monoclonal protein in different renal structures, as well as indirect mechanisms, acting as an autoantibody provoking dysregulation of the alternative complement pathway. The detection of this monoclonal protein and an early hematologic study are essential, as is the need for a kidney biopsy to establish the associated nephropathological diagnosis. Consequently, this then leads to the start of specific hematologic treatment to detain the production of the monoclonal protein and minimize renal and systemic injury. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.
PB Soc espanola nefrologia dr rafael matesanz
SN 0211-6995
YR 2021
FD 2021-09-01
LK https://hdl.handle.net/10668/24548
UL https://hdl.handle.net/10668/24548
LA en
DS RISalud
RD Apr 7, 2025