TY - JOUR AU - Tap, William D AU - Gelderblom, Hans AU - Palmerini, Emanuela AU - Desai, Jayesh AU - Bauer, Sebastian AU - Blay, Jean-Yves AU - Alcindor, Thierry AU - Ganjoo, Kristen AU - Martin-Broto, Javier AU - Ryan, Christopher W AU - Thomas, David M AU - Peterfy, Charles AU - Healey, John H AU - van-de-ande, Michiel AU - Gelhorn, Heather L AU - Shuster, Dale E AU - Wang, Qiang AU - Yver, Antoine AU - Hsu, Henry H AU - Lin, Paul S AU - Tong-Starksen, Sandra AU - Stacchiotti, Silvia AU - Wagner, Andrew J PY - 2019 DO - 10.1016/S0140-6736(19)30764-0 UR - http://hdl.handle.net/10668/14158 T2 - Lancet (London, England) AB - Background: Tenosynovial giant cell tumour (TGCT), a rare, locally aggressive neoplasm , overexpresses colony-stimulating factor 1 (CSF1). Surgery is standard with no approved systemic therapy . We aimed to evaluate pexidartinib, a CSF1 receptor... LA - en PB - The Lancet Publishing Group KW - Antineoplastic Agents KW - Double-Blind Method KW - Intention to Treat Analysis KW - Young Adult KW - Treatment Outcome KW - Adult KW - Aged KW - Female KW - Giant Cell Tumor of Tendon Sheath KW - Humans KW - Male KW - Middle Aged KW - Protein Kinase Inhibitors KW - Response Evaluation Criteria in Solid Tumors KW - Survival Analysis TI - Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. TY - research article VL - 394 ER -