TY  - JOUR
AU  - García-León, Juan Antonio
AU  - Cabrera-Socorro, Alfredo
AU  - Eggermont, Kristel
AU  - Swijsen, Ann
AU  - Terryn, Joke
AU  - Fazal, Raheem
AU  - Nami, FatemehArefeh
AU  - Ordovás, Laura
AU  - Quiles, Ana
AU  - Lluis, Frederic
AU  - Serneels, Lutgarde
AU  - Wierda, Keimpe
AU  - Sierksma, Annerieke
AU  - Kreir, Mohamed
AU  - Pestana, Francisco
AU  - Van Damme, Philip
AU  - De Strooper, Bart
AU  - Thorrez, Lieven
AU  - Ebneth, Andreas
AU  - Verfaillie, Catherine M
PY  - 2018
DO  - 10.1016/j.jalz.2018.05.007
UR  - http://hdl.handle.net/10668/12743
T2  - Alzheimer's & dementia : the journal of the Alzheimer's Association
AB  - Tauopathies are neurodegenerative diseases characterized by TAU protein-related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but none of them faithfully recapitulates human...
LA  - en
KW  - Alzheimer's disease
KW  - CRISPR-Cas
KW  - Disease modeling
KW  - Drug screening
KW  - Frontotemporal dementia
KW  - Neurodegeneration
KW  - Parkinsonism linked to chromosome 17
KW  - Progressive supranuclear palsy
KW  - Tauopathies
KW  - CRISPR-Cas Systems
KW  - Cell Line
KW  - Humans
KW  - Induced Pluripotent Stem Cells
KW  - Membrane Potentials
KW  - Mutation
KW  - Nerve Degeneration
KW  - Neurogenesis
KW  - Neuronal Outgrowth
KW  - Neurons
KW  - Phenotype
KW  - Tauopathies
KW  - Transcriptome
KW  - tau Proteins
TI  - Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.
TY  - research article
VL  - 14
ER  -