RT Journal Article
T1 TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.
A1 Canhão, Helena
A1 Rodrigues, Ana Maria
A1 Santos, Maria José
A1 Carmona-Fernandes, Diana
A1 Bettencourt, Bruno F
A1 Cui, Jing
A1 Rocha, Fabiana L
A1 Canas Silva, José
A1 Polido-Pereira, Joaquim
A1 Pereira Silva, José Alberto
A1 Costa, José António
A1 Araujo, Domingos
A1 Silva, Cândida
A1 Santos, Helena
A1 Duarte, Cátia
A1 Cáliz, Rafael
A1 Filipescu, Ileana
A1 Pimentel-Santos, Fernando
A1 Branco, Jaime
A1 Sainz, Juan
A1 Plenge, Robert M
A1 Solomon, Daniel H
A1 Bruges-Armas, Jácome
A1 Da Silva, José António P
A1 Fonseca, João Eurico
A1 Karlson, Elizabeth W
K1 Antirreumáticos
K1 Artritis reumatoide
K1 Factor de necrosis tumoral alfa
K1 Humanos
K1 Factor 1 asociado a receptor de TNF
K1 Modelos logísticos
K1 Grupo de ascendencia continental europea
K1 Alelos
AB BACKGROUNDThe aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response.METHODSWe evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to confirm our findings, we pooled our population with 265 Spanish patients.RESULTSNo association was found between PTPRC rs10919563 allele and anti-TNF treatment response, neither in Portuguese modeling for several clinical variables nor in the overall population combining Portuguese and Spanish patients. The minor allele for RA susceptibility, rs3761847 SNP in TRAF1/C5 region, was associated with a poor response in linear and logistic univariate and multivariate regression analyses. No association was observed with the other allellic variants. Results were confirmed in the pooled analysis.CONCLUSIONThis study did not replicate the association between PTPRC and the response to anti-TNF treatment in our Southern European population. We found that TRAF1/C5 risk RA variants potentially influence anti-TNF treatment response.
PB Hindawi Publishing Corporation
YR 2015
FD 2015
LK http://hdl.handle.net/10668/2093
UL http://hdl.handle.net/10668/2093
LA en
NO Canhão H, Rodrigues AM, Santos MJ, Carmona-Fernandes D, Bettencourt BF, Cui J, et al. TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy. Biomed Res Int; 2015:490295
NO Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025