RT Journal Article
T1 Whole Exome Sequencing of Patients from Multicase Families with Systemic Lupus Erythematosus Identifies Multiple Rare Variants.
A1 Delgado-Vega, Angélica M
A1 Martínez-Bueno, Manuel
A1 Oparina, Nina Y
A1 López Herráez, David
A1 Kristjansdottir, Helga
A1 Steinsson, Kristján
A1 Kozyrev, Sergey V
A1 Alarcón-Riquelme, Marta E
AB In an effort to identify rare alleles associated with SLE, we have performed whole exome sequencing of the most distantly related affected individuals from two large Icelandic multicase SLE families followed by Ta targeted genotyping of additional relatives. We identified multiple rare likely pathogenic variants in nineteen genes co-segregating with the disease through multiple generations. Gene co-expression and protein-protein interaction analysis identified a network of highly connected genes comprising several loci previously implicated in autoimmune diseases. These genes were significantly enriched for immune system development, lymphocyte activation, DNA repair, and V(D)J gene recombination GO-categories. Furthermore, we found evidence of aggregate association and enrichment of rare variants at the FAM71E1/EMC10 locus in an independent set of 4,254 European SLE-cases and 4,349 controls. Our study presents evidence supporting that multiple rare likely pathogenic variants, in newly identified genes involved in known disease pathogenic pathways, segregate with SLE at the familial and population level.
YR 2018
FD 2018-06-08
LK http://hdl.handle.net/10668/12568
UL http://hdl.handle.net/10668/12568
LA en
DS RISalud
RD Apr 8, 2025