RT Journal Article
T1 Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism.
A1 Ruiz-Ojeda, Francisco Javier
A1 Anguita-Ruiz, Augusto
A1 Ruperez, Azahara I
A1 Gomez-Llorente, Carolina
A1 Olza, Josune
A1 Vazquez-Cobela, Rocio
A1 Gil-Campos, Mercedes
A1 Bueno, Gloria
A1 Leis, Rosaura
A1 Cañete, Ramon
A1 Moreno, Luis A
A1 Gil, Angel
A1 Aguilera, Concepcion Maria
K1 Adipocytes
K1 Adult
K1 Child
K1 Diabetes mellitus, type 2
AB Tenomodulin (TNMD) is a type II transmembrane glycoprotein that has been recently linked to obesity, and it is highly expressed in obese adipose tissue. Several sex-dependent associations have been observed between single-nucleotide polymorphisms (SNPs) of the TNMD gene, which is located in the X-chromosome, and obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome in adults. On the other hand, results are lacking for children. We aimed (i) to study the association between TNMD genetic variants and metabolic complications related to childhood obesity and (ii) to investigate the function of TNMD in human adipocytes. We conducted a case-control, multicenter study in 915 Spanish children and demonstrated significant positive associations between TNMD genetic variants and BMI z-score, waist circumference, fasting glucose, and insulin resistance in boys, highlighting the SNP rs4828038. Additionally, we showed a BMI-adjusted inverse association with waist circumference in girls. Second, in vitro experiments revealed that TNMD is involved in adipogenesis, along with glucose and lipid metabolism in differentiated adipocytes, and these effects may be mediated through AMPK activation. Hence, these results suggest that TNMD genetic variants could be potentially useful as early life risk indicators for obesity and T2DM. In addition, we support the fact that TNMD exhibits significant metabolic functions in adipocytes.
PB Nature Publishing Group
YR 2018
FD 2018-10-18
LK http://hdl.handle.net/10668/13680
UL http://hdl.handle.net/10668/13680
LA en
NO Ruiz-Ojeda FJ, Anguita-Ruiz A, Rupérez AI, Gomez-Llorente C, Olza J, Vázquez-Cobela R, et al. Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism. Sci Rep. 2019 Mar 8;9(1):3979
NO Tis work was supported by Plan Nacional de Investigación Científca, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (Projects numbers PI020826, PI051968, PI1102042, PI1600871), RETIC (Red SAMID RD12/0026/0015), Fondo Europeo De Desarrollo Regional (FEDER) and the Junta de Andalucía (project number CTS-6770); Secretaría General de Universidades, Investigación y Tecnología. Consejería de Economía, Innovación y Ciencia). Te funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Tis paper will be part of Augusto Anguita-Ruiz’s doctorate, which is being performed under the “Nutrition and Food Sciences Program” at the University of Granada.
DS RISalud
RD Apr 11, 2025