TY  - JOUR
AU  - Ramírez, Alberto
AU  - Boulaiz, Houria
AU  - Morata-Tarifa, Cynthia
AU  - Perán, Macarena
AU  - Jiménez, Gema
AU  - Picon-Ruiz, Manuel
AU  - Agil, Ahmad
AU  - Cruz-López, Olga
AU  - Conejo-García, Ana
AU  - Campos, Joaquín M
AU  - Sánchez, Ana
AU  - García, María A
AU  - Marchal, Juan A
PY  - 2014
UR  - http://hdl.handle.net/10668/2277
T2  - Oncotarget
AB  - Identification of novel anticancer drugs presenting more than one molecular target and efficacy against cancer stem-like cells (CSCs) subpopulations represents a therapeutic need to combat the resistance and the high risk of relapse in patients. In...
LA  - en
PB  - Impact Journals
KW  - HER-2
KW  - Bozepinib
KW  - Protein kinases
KW  - Cancer stem-like cells
KW  - Metastasis
KW  - Animales
KW  - Carcinogénesis
KW  - Neoplasias del colon
KW  - Regulación hacia abajo
KW  - Femenino
KW  - Erizos
KW  - Humanos
KW  - Ratones desnudos
KW  - Recurrencia local de neoplasia
KW  - Células madre neoplásicas
KW  - Oxazepinas
KW  - Purinas
KW  - Piranos
KW  - Receptor ErbB-2
KW  - Transducción de señal
KW  - Regulación hacia arriba
KW  - Factor A de crecimiento endotelial vascular
KW  - beta Catenina
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Cocarcinogenesis
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Colonic Neoplasms
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Down-Regulation
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Insectivora::Hedgehogs
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Nude
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local
KW  - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azepines::Oxazepines
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Pyrans
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases::Receptor, erbB-2
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Up-Regulation
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Angiogenic Proteins::Vascular Endothelial Growth Factors::Vascular Endothelial Growth Factor A
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Armadillo Domain Proteins::beta Catenin
TI  - HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound.
TY  - research article
ER  -