RT Journal Article
T1 Menstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spain.
A1 Lope, Virginia
A1 Fernandez de Larrea, Nerea
A1 Perez-Gomez, Beatriz
A1 Martin, Vicente
A1 Moreno, Victor
A1 Costas, Laura
A1 Longo, Federico
A1 Jimenez-Moleon, Jose Juan
A1 Llorca, Javier
A1 Ascunce, Nieves
A1 Peiro-Perez, Rosana
A1 Altzibar, Jone M
A1 Tardon, Adonina
A1 Alguacil, Juan
A1 Navarro, Carmen
A1 Sierra, Angeles
A1 Vega, Ana Belen
A1 Villafañe, Amaya
A1 Castaño-Vinyals, Gemma
A1 Kogevinas, Manolis
A1 Pollan, Marina
A1 Aragones, Nuria
K1 Case-Control Studies
K1 Colorectal Neoplasms
K1 Female
K1 Humans
AB Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province. Demographic and reproductive data were directly surveyed by trained staff. The association with gastric, colon and rectal cancer was assessed using logistic and multinomial mixed regression models. Our results show an inverse association of age at first birth with gastric cancer risk (five-year trend: OR = 0.69; p-value = 0.006). Ever users of hormonal contraception presented a decreased risk of gastric (OR = 0.42; 95%CI = 0.26-0.69), colon (OR = 0.64; 95%CI = 0.48-0.86) and rectal cancer (OR = 0.61; 95%CI = 0.43-0.88). Postmenopausal women who used hormone replacement therapy showed a decreased risk of colon and rectal tumors. A significant interaction of educational level with parity and months of first child lactation was also observed. These findings suggest a protective role of exogenous hormones in gastric and colorectal cancer risk. The role of endogenous hormones remains unclear.
PB Public Library of Science
YR 2016
FD 2016-09-28
LK http://hdl.handle.net/10668/10557
UL http://hdl.handle.net/10668/10557
LA en
NO Lope V, Fernández de Larrea N, Pérez-Gómez B, Martín V, Moreno V, Costas L, et al. Menstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spain. PLoS One. 2016 Oct 24;11(10):e0164620.
DS RISalud
RD Apr 18, 2025