RT Generic
T1 Pleiotropic Role of Puupehenones in Biomedical Research
A1 Martinez-Poveda, Beatriz
A1 Quesada, Ana R.
A1 Angel Medina, Miguel
K1 puupehenones
K1 sponges
K1 marine drugs
K1 antiangiogenic
K1 antitumoral
K1 Marine natural-products
K1 Enantiospecific synthesis
K1 Sponge metabolites
K1 Antioxidant power
K1 Tetracyclic core
K1 Quinone-methide
K1 Nadph oxidases
K1 8-epipuupehedione
K1 Pathophysiology
K1 (+)-puupehenone
AB Marine sponges represent a vast source of metabolites with very interesting potential biomedical applications. Puupehenones are sesquiterpene quinones isolated from sponges of the orders Verongida and Dictyoceratida. This family of chemical compounds is composed of a high number of metabolites, including puupehenone, the most characteristic compound of the family. Chemical synthesis of puupehenone has been reached by different routes, and the special chemical reactivity of this molecule has allowed the synthesis of many puupehenone-derived compounds. The biological activities of puupehenones are very diverse, including antiangiogenic, antitumoral, antioxidant, antimicrobial, immunomodulatory and antiatherosclerotic effects. Despite the very important roles described for puupehenones concerning different pathologies, the exact mechanism of action of these compounds and the putative therapeutic effects in vivo remain to be elucidated. This review offers an updated and global view about the biology of puupehenones and their therapeutic possibilities in human diseases such as cancer.
PB Mdpi ag
SN 1660-3397
YR 2017
FD 2017-10-01
LK http://hdl.handle.net/10668/19301
UL http://hdl.handle.net/10668/19301
LA en
DS RISalud
RD May 13, 2025