RT Journal Article
T1 Effectiveness of the Unified Barlow Protocol (UP) and neuropsychological treatment in cancer survivors for cognitive impairments: study protocol for a randomized controlled trial.
A1 Garcia-Torres, Francisco
A1 Tejero-Perea, Adrián
A1 Gomez-Solis, Angel
A1 Castillo-Mayen, Rosario
A1 Jaen-Moreno, Maria Jose
A1 Luque, Barbara
A1 Galvez-Lara, Mario
A1 Sanchez-Raya, Araceli
A1 Jablonski, Marcin
A1 Rodriguez-Alonso, Beatriz
A1 Aranda, Enrique
K1 Anxiety and depression
K1 Cancer
K1 Cognitive impairment
K1 Oncology
K1 Quality of life
K1 Unified protocol for transdiagnostic treatment of emotional disorders (UP)
AB Cancer survivors frequently develop cognitive impairment, which negatively affects their quality of life and emotional well-being. This study compares the effectiveness of a well-established treatment (neuropsychological treatment) with the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) to reduce these cognitive deficits and evaluate the effect of both treatments on anxiety-depressive symptoms and the quality of life of cancer survivors. A three-arm, randomized superiority clinical trial with a pre-post and repeated follow-up measures intergroup design using a 1:1:1 allocation ratio will be performed. One hundred and twenty-three cancer survivors with mild to moderate cognitive impairment will be randomly assigned to one of the study interventions: a cognitive rehabilitation intervention group, an intervention group with UP intervention, or a control group on the waiting list. The primary outcome is to observe a significant improvement in cognitive function in both intervention groups and a significant decrease in emotional impairments in comparison with the waitlist group. Improvements in anxiety, depression, and quality of life are also expected as secondary outcomes. These results will be maintained at 6 months of follow-up. The aim of this trial is to test the efficacy of the UP intervention in reducing cognitive deficits in breast cancer survivors. The results of this trial may be useful in reducing the presence of cognitive problems in cancer survivors and improving their emotional state and quality of life. 
PB BioMed Central
YR 2022
FD 2022-09-12
LK http://hdl.handle.net/10668/20356
UL http://hdl.handle.net/10668/20356
LA en
NO García-Torres F, Tejero-Perea A, Gómez-Solís Á, Castillo-Mayén R, Jaén-Moreno MJ, Luque B, Gálvez-Lara M, et al. Effectiveness of the Unified Barlow Protocol (UP) and neuropsychological treatment in cancer survivors for cognitive impairments: study protocol for a randomized controlled trial. Trials. 2022 Sep 30;23(1):819
DS RISalud
RD Apr 6, 2025