TY  - JOUR
AU  - Bouriche, Sihem
AU  - Alonso-García, Angela
AU  - Cárceles-Rodríguez, Carlos M.
AU  - Rezgui, Farouk
AU  - Fernández-Varón, Emilio
PY  - 2021
DO  - 10.1186/s12917-021-03016-3
UR  - http://hdl.handle.net/10668/4270
T2  - BMC Veterinary Research
AB  - BackgroundMetformin hydrochloride is a biguanide derivative that has been widely used to treat type 2 diabetes in humans. In veterinary medicine, metformin has shown increasing potential for diabetes treatment in different species, such as equids,...
LA  - en
PB  - BMC Part of Springer Nature
KW  - Metformin
KW  - Controlled-release
KW  - Microparticles
KW  - Pharmacokinetics
KW  - Polymeric-based formulations
KW  - Diabetes Mellitus, Type 2
KW  - Calorimetry, differential scanning
KW  - Half-Life
KW  - Spectroscopy, Fourier transformifrared
KW  - Lactic acid
KW  - Metformina
KW  - Preparaciones de acción retardada
KW  - Microplásticos
KW  - Farmacocinética
KW  - Diabetes mellitus tipo 2
KW  - Rastreo diferencial de calorimetría
KW  - Semivida
KW  - Espectroscopía infrarroja por transformada de Fourier
KW  - Ácido láctico
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Intravenous
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Oral
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Delayed-Action Preparations
KW  - Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Half-Life
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amidines::Guanidines::Biguanides::Metformin
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Physicochemical Phenomena::Particle Size
KW  - Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Polyesters
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Lagomorpha::Rabbits
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Carnivora::Canidae::Dogs
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Perissodactyla::Equidae::Horses
KW  - Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Calorimetry::Calorimetry, Differential Scanning
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Pharmacokinetics::Biological Availability
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Fourier Analysis
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Physicochemical Processes::Hydrogen Bonding
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Spectrum Analysis::Spectrophotometry::Spectrophotometry, Infrared::Spectroscopy, Fourier Transform...
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Crystallography::X-Ray Diffraction
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amidines::Guanidines::Biguanides::Metformin
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Hydroxy Acids::Lactates::Lactic Acid
TI  - An in vivo pharmacokinetic study of metformin microparticles as an oral sustained release formulation in rabbits
TY  - research article
ER  -